Historical Notes on Cancer

Ackerknecht, Erwin H.

doi:10.1017/s0025727300023528

Cited by 22 publications

(22 citation statements)

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“…Julius Cohnheim (1839-1884) was perhaps the first person to propose the embryonic origin of cancer (Capp, 2019), influenced by his teacher Rudolf Virchow (1821-1902) (Ackerknecht, 1958). This parallel between normal developmental process in embryo and cancer in adults can be called “oncogenesis recapitulating ontogenesis” (Huang et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

A Higher Proportion of Craniosynostosis Genes Are Cancer Driver Genes

Misra

Shih

Yan

et al. 2019

Preprint

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Craniosynostosis (CRS) is a congenital abnormality deformity with a heterogenous genetic contribution. Previously, there are two attempts to collect genes that are genetically associated with craniosynostosis and some related syndromes with 57 (Twigg and Wilkie, 2015) and 39 (Goos and Mathijssen, 2019) genes identified, respectively. We expanded this list of craniosynostosis genes by adding another 17 genes with an updated literature search. These genes are shown to be more likely to be intolerant to functional mutations. Of these 113 craniosynostosis genes, 21 (19% vs. 1.5% baseline frequency) are cancer driver genes, a 14-fold enrichment. The cancer-craniosynostosis connection is further validated by an over-representation analysis of craniosynostosis genes in KEGG cancer pathway and several cancer related gene-sets. Many cancer-craniosynostosis overlapping genes participate in intracellular signaling pathways, which play a role in both development and cancer. This connection can be viewed from the oncogenesis recapitulates ontogenesis framework. Nineteen craniosynostosis genes are transcription factor genes (16.8% vs. 8.2% baseline), and craniosynostosis genes are also enriched in targets of certain transcription factors or micro RNAs.

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Section: Discussionmentioning

confidence: 99%

A Higher Proportion of Craniosynostosis Genes Are Cancer Driver Genes

Misra

Shih

Yan

et al. 2019

Preprint

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“…Not long ago, Ackerknecht [13] acknowledged the need to know the historical origins of cancer. As he put it, "The first task faced by medicine was to discover clinically and macroscopically the different forms of cancer and to unite them in some common notion; more recently some knowledge as to its microscopic morphology [14], its physiology and causative factors has been acquired and some new therapeutic agents have been discovered. "…”

Section: Discussionmentioning

confidence: 99%

Methodological Search for Historical Evidence of Melanomas Spreading to the Skin

Onuigbo¹

2016

J Med Diagn Meth

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“…All nonliterate groups have articulated beliefs and explanations about disease (14). Rather than viewing these beliefs as naive and superstitious, they must be seen as adaptive and "designed" to resolve the crisis and uncertainty surrounding disease by explaining the causes of disease and rationalizing treatment.…”

Section: Insights Drawn From Ethnomedicinementioning

confidence: 99%

The Need for an Ethnomedical Science

Fàbrega

1975

Science

193

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Ethnomedicine is an intellectual area which embraces theoretical concerns that are relevant to both the social and biological sciences. The relation which exists between disease, social behavior, and human adaptation constitutes the primary subject matter of ethnomedicine. This relation is examined in terms of man's unique capacities for symbolization and culture. Since ethnomedical generalizations explain how social groups deal with a generic disease, they can be used to examine contemporary problems which involve the organization and practice of medicine as well as problems that stem from relations of the medical system with other subsystems in the group. Recasting contemporary social problems in this way may help to clarify their roots and sources (13,28). In focusing on fundamental properties of disease in man, ethnomedicine can also help to clarify the effects and meanings of disease and thereby make its control more rational. A theory of disease, an ultimate aim of ethnomedical inquiry, will serve as an explanatory device with wide-ranging applications.

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Historical Notes on Cancer

Cited by 22 publications

References 0 publications

A Higher Proportion of Craniosynostosis Genes Are Cancer Driver Genes

A Higher Proportion of Craniosynostosis Genes Are Cancer Driver Genes

Methodological Search for Historical Evidence of Melanomas Spreading to the Skin

The Need for an Ethnomedical Science

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