Historical Evolution of Skin Grafting—A Journey through Time

Kohlhauser, Michael; Luze, Hanna; Nischwitz, Sebastian P.; Kamolz, Lars Peter

doi:10.3390/medicina57040348

Cited by 43 publications

(61 citation statements)

References 124 publications

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“…At the same time, drainage is as important as preventing bleeding that plasma drainage tubes or making meshes in skin grafts are both versatile methods. We think making 2 ~ 3 meshes enable skin grafts to expand, and are convenient, with less potential for infection compared with plasma tube insertion 30 . Based on reasons above, we recommend this simple technique for closure of tibial defects which has got support from another study 31 .…”

Section: Discussionmentioning

confidence: 99%

Free posterior tibial artery perforator flapin head and neck reconstruction after tumor expiration

Shi

Deng

et al. 2022

Preprint

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Objectives: The purpose of this study was to examine the anatomical features, clinical applications, and complications of the free posterior tibial flap in head and neck reconstruction.Methods： Patients treated with free posterior tibial artery perforator flap in head and neck surgery were retrospectively viewed. Results： A total of 55 patients underwent reconstruction with a free posterior tibial artery perforator flap. Most of the patients had carcinoma of pharynx, trachea, oral and maxillofacial region. The flap dimension ranged from 7.5 cm2 to 108 cm2. The mean thickness of the flap was 1cm. The average length of the vascular pedicle is about 10 cm. Functional recovery of reconstruction area was studied 5~100 months after surgery. The flap survival rate was 98.1%. Specifically speaking, 3 patients developed Partial flap loss and 1 patient developed Total flap loss. Regarding ablative site complications, 6 patients developed wound infection, 2 of them, and another 2 patients developed pharyngeal fistula in the ablative area. Regarding donor site complications, 7 patients developed delayed wound healing and 5 patients developed skin graft necrosis. None of the patients complained of walking difficulty in daily life.Conclusion: Free posterior tibial artery perforator flap as a relatively novel flap, with stable blood supply, thin thickness, flexible cortex, long vascular pedicle, and concealed donor area, is very suitable for head and neck reconstruction. Though PTAFs harvest will produce a minor donor site morbidity which could be solved mostly by conservative treatment, we think PTAFs will become one of the popular techniques for reconstruction of head and neck soft tissue defects.

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Section: Discussionmentioning

confidence: 99%

Free posterior tibial artery perforator flapin head and neck reconstruction after tumor expiration

Shi

Deng

et al. 2022

Preprint

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“…However, quite surprisingly, skin grafting is not a new concept; for the past 3500 years, it has been extensively practised by a string of renowned physicians. These include Aulus Cornelius Celsus (25 BC -50 AD), the Roman author of the first systematic treatise on Medicine; Claudius Gelenus (129 AD -210 AD) popularly known as Galen, a prominent Greek physician; Jaques-Louis Reverdin (1842-1929), the Swiss surgeon who performed the first "fresh skin" allograft; and George David Pollock (1817-1897), a British surgeon known as a pioneer of skin grafts [16][17][18][19][20][21][22][23][24]. Throughout the years, the roles and functions of skin grafting have expanded.…”

Section: History Of Wound Care and Wound Dressingmentioning

confidence: 99%

HaruanExtract (Channa striatus) as an Effective Mediator in Promoting Wound Healing

Musa¹,

Min²

2022

Skin Grafts for Successful Wound Closure

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Wound healing remains a major issue in surgery. None of the existing treatment modalities in caring for wounds can yet claim to be the holy grail of wound management. Channa striatus, locally known in Malaysia as Haruan, is a freshwater air-breathing carnivorous fish that is proven to influence the different phases of wound healing. As a medicinal fish, not only does Haruan have a high content of amino and fatty acids, which are essential in collagen fibre synthesis during wound recovery, it also abounds in arachidonic acid and polyunsaturated fatty acids that promote prostaglandin synthesis, a vital component of the healing process. Moreover, its antinociceptive effects could potentially reduce wound pain, an important factor in wound healing. Proteomic studies show that a quarter of the total protein detected in freeze- and spray-dried C. striatus extract are actin, myosin and tropomyosin – all molecules that play a role in the wound healing process. Proteomic profiling also reveals that Haruan possesses two types of collagen namely collagen type-I and type-II that confer tensile strength during the healing process. It is proven that collagen along with other components of the extracellular matrix form the granulation tissue which, when contracted, closes the wound and concomitantly aligns the collagen fibres in the extracellular matrix. Hence, it is inferred that Haruan promotes the maturation of granulation tissue, thereby expediting the wound healing process itself. Consequently, it could mediate a faster recovery from surgical wound coupled with a lower incidence of wound infection due to an improved and accelerated wound healing process. Additionally, Haruan has demonstrated its ability in promoting angiogenesis and cell proliferation in wound bed preparation for skin grafting. Furthermore, a Haruan aerosol concentrate can act as a wound dressing at the donor site thereby enhancing the healing process while simultaneously exhibiting some antinociceptive properties. Haruan’s exceptional ability in promoting wound healing together with its potential use in skin grafting would be instrumental in the field of surgery. In essence, the cumulated benefits from all the processes involved would translate into a significant reduction of hospitalisation cost; that would immensely benefit not only the patient, but also the government.

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“…1 It also protects from external factors such as pathogens, mechanical forces, and UV radiation. 2 The skin accomplishes this by being composed of three layers:, epidermis, dermis, and hypodermis. The epidermis is further composed of five layers: the stratum corneum, lucidum, granulosum, spinosum, and basale.…”

Section: General Introduction To Burns and Function Of Skinmentioning

confidence: 99%

The Role of Skin Substitutes in Acute Burn and Reconstructive Burn Surgery: An Updated Comprehensive Review

et al. 2022

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Burns disrupt the protective skin barrier with consequent loss of cutaneous temperature regulation, infection prevention, evaporative losses, and other vital functions. Chronically, burns lead to scarring, contractures, pain, and impaired psychosocial well-being. Several skin substitutes are available and replace the skin and partially restore functional outcomes and improve cosmesis. We performed a literature review to update readers on biologic and synthetic skin substitutes to date applied in acute and reconstructive burn surgery. Improvement has been rapid in the development of skin substitutes in the last decade; however, no available skin substitute fulfills criteria as a perfect replacement for damaged skin.

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Historical Evolution of Skin Grafting—A Journey through Time

Cited by 43 publications

References 124 publications

Free posterior tibial artery perforator flapin head and neck reconstruction after tumor expiration

Free posterior tibial artery perforator flapin head and neck reconstruction after tumor expiration

HaruanExtract (Channa striatus) as an Effective Mediator in Promoting Wound Healing

The Role of Skin Substitutes in Acute Burn and Reconstructive Burn Surgery: An Updated Comprehensive Review

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