Histopathology of the Kveim Test

Sarcoidosis

“…Early descriptions of the histology include those of Putkonen (1945), Rogers and Haserick (1954), Siltzbach and Ehrlich (1954), James and Thomson (1955), Nelson (1957), andSteigleder et al (1961). lt is generally agreed that the typical reaction, consisting in well-formed tuberculoid collections of epithelioid cells with or without giant cells, and with limited or negligible lymphocytic infiltration, begins to develop within two weeks but does not attain a fully characteristic appearance until later .…”

“…Steigleder et al (1961) reported that of 83 reactions which they accepted as specific, rather over one-third showed granulomas of typically sarcoid appearance; among the rest about one-half showed similar granulomas but with some necrosis and banal inflammatory reaction, and one half a less well-formed tuberculoid granuloma. Reactions with many giant cells, some containing doubly refractile particles, are especially liable to varied interpretation.…”

Reactions Evoked with Intradermal Injections of Normal Human Tissue Suspensions; Comparison with the Kveim Test

“…The dermal reactions evoked with these suspen sions were reviewed in order of the histological classification of Kveim tests given by Steigleder, Silva and Nelson (1961).…”