Histopathology of Otosclerosis

Quantification of Angiogenesis in Otosclerosis

“…We observed that a significantly greater proportion of clinical cases demonstrated vascular connection to nearby vessels. Our findings agree with Nager's 19 original description of the arterial supply to otosclerotic foci (two branches of the middle meningeal artery, the superficial petrosal, and the superior tympanic). However, because the artery entering otosclerotic foci was usually observed adjacent to Jacobson's nerve, we named it the inferior rather than superior tympanic artery (because these two arteries anastomose anterior to the oval window, the distinction may not be important).…”

Quantification of Angiogenesis in Otosclerosis

“…We observed that a significantly greater proportion of clinical cases demonstrated vascular connection to nearby vessels. Our findings agree with Nager's 19 original description of the arterial supply to otosclerotic foci (two branches of the middle meningeal artery, the superficial petrosal, and the superior tympanic). However, because the artery entering otosclerotic foci was usually observed adjacent to Jacobson's nerve, we named it the inferior rather than superior tympanic artery (because these two arteries anastomose anterior to the oval window, the distinction may not be important).…”

Synchrotron Phase-Contrast Imaging and Cochlear Otosclerosis: A Case Report

“…In the otosclerotic ear, however, vascular channels or shunts formed communication pathways between lesions and the inner ear blood system. This coincides with histological descriptions of vascular shunts present in cochlear otosclerosis [ 1 , 11 – 13 ]. In addition, rich arterial connections were found between lesions and vascular collaterals to the horizontal portion of the facial nerve and its outer knee.…”

“…A prominent feature of active otospongiotic lesions is the large number of dilated vascular channels together with inflammatory-like lytic changes with the accumulation of osteoblasts and active osteoclasts [ 2 , 6 , 41 ]. According to Nager [ 13 ], otosclerotic lesions at the oval window are supplied by vessels over the promontory mucoperiosteum and branches from the internal auditory, middle meningeal, superficial petrosal, and superior tympanic arteries [ 13 ]. The superficial petrosal and superior tympanic veins were said to drain the venous blood from the lesion at the oval window following the arteries.…”

Imaging Evaluation in Otosclerosis: Single Photon Emission Computed Tomography and Computed Tomography

“…Regarding the bilaterality of the disease, no statistically significant difference was found between the UI values for the two ears of the same subject -a finding demonstrating that otosclerosis is in most cases a bilateral disorder, as reported in the literature. [43][44][45][46][47] Regarding the uptake of the bony labyrinth in relation to age, the mean UI value in the younger subjects (2.540) was significantly higher than that of the older subjects (1.730; p < 0.0001). Thus, an inverse relationship was found between petrosal UI values and age.…”

Quantification of Angiogenesis in Otosclerosis

“…We observed that a significantly greater proportion of clinical cases demonstrated vascular connection to nearby vessels. Our findings agree with Nager's 19 original description of the arterial supply to otosclerotic foci (two branches of the middle meningeal artery, the superficial petrosal, and the superior tympanic). However, because the artery entering otosclerotic foci was usually observed adjacent to Jacobson's nerve, we named it the inferior rather than superior tympanic artery (because these two arteries anastomose anterior to the oval window, the distinction may not be important).…”

Synchrotron Phase-Contrast Imaging and Cochlear Otosclerosis: A Case Report

“…In the otosclerotic ear, however, vascular channels or shunts formed communication pathways between lesions and the inner ear blood system. This coincides with histological descriptions of vascular shunts present in cochlear otosclerosis [ 1 , 11 – 13 ]. In addition, rich arterial connections were found between lesions and vascular collaterals to the horizontal portion of the facial nerve and its outer knee.…”

“…A prominent feature of active otospongiotic lesions is the large number of dilated vascular channels together with inflammatory-like lytic changes with the accumulation of osteoblasts and active osteoclasts [ 2 , 6 , 41 ]. According to Nager [ 13 ], otosclerotic lesions at the oval window are supplied by vessels over the promontory mucoperiosteum and branches from the internal auditory, middle meningeal, superficial petrosal, and superior tympanic arteries [ 13 ]. The superficial petrosal and superior tympanic veins were said to drain the venous blood from the lesion at the oval window following the arteries.…”

Imaging Evaluation in Otosclerosis: Single Photon Emission Computed Tomography and Computed Tomography

“…Regarding the bilaterality of the disease, no statistically significant difference was found between the UI values for the two ears of the same subject -a finding demonstrating that otosclerosis is in most cases a bilateral disorder, as reported in the literature. [43][44][45][46][47] Regarding the uptake of the bony labyrinth in relation to age, the mean UI value in the younger subjects (2.540) was significantly higher than that of the older subjects (1.730; p < 0.0001). Thus, an inverse relationship was found between petrosal UI values and age.…”

Quantification of Angiogenesis in Otosclerosis

“…We observed that a significantly greater proportion of clinical cases demonstrated vascular connection to nearby vessels. Our findings agree with Nager's 19 original description of the arterial supply to otosclerotic foci (two branches of the middle meningeal artery, the superficial petrosal, and the superior tympanic). However, because the artery entering otosclerotic foci was usually observed adjacent to Jacobson's nerve, we named it the inferior rather than superior tympanic artery (because these two arteries anastomose anterior to the oval window, the distinction may not be important).…”

Synchrotron Phase-Contrast Imaging and Cochlear Otosclerosis: A Case Report

“…In the otosclerotic ear, however, vascular channels or shunts formed communication pathways between lesions and the inner ear blood system. This coincides with histological descriptions of vascular shunts present in cochlear otosclerosis [ 1 , 11 – 13 ]. In addition, rich arterial connections were found between lesions and vascular collaterals to the horizontal portion of the facial nerve and its outer knee.…”

“…A prominent feature of active otospongiotic lesions is the large number of dilated vascular channels together with inflammatory-like lytic changes with the accumulation of osteoblasts and active osteoclasts [ 2 , 6 , 41 ]. According to Nager [ 13 ], otosclerotic lesions at the oval window are supplied by vessels over the promontory mucoperiosteum and branches from the internal auditory, middle meningeal, superficial petrosal, and superior tympanic arteries [ 13 ]. The superficial petrosal and superior tympanic veins were said to drain the venous blood from the lesion at the oval window following the arteries.…”

Imaging Evaluation in Otosclerosis: Single Photon Emission Computed Tomography and Computed Tomography

“…Regarding the bilaterality of the disease, no statistically significant difference was found between the UI values for the two ears of the same subject -a finding demonstrating that otosclerosis is in most cases a bilateral disorder, as reported in the literature. [43][44][45][46][47] Regarding the uptake of the bony labyrinth in relation to age, the mean UI value in the younger subjects (2.540) was significantly higher than that of the older subjects (1.730; p < 0.0001). Thus, an inverse relationship was found between petrosal UI values and age.…”