Histopathology of hepatocellular carcinoma

Schlageter, Manuel; Terracciano, Luigi; D’Angelo, Salvatore; Sorrentino, Paolo

doi:10.3748/wjg.v20.i43.15955

Cited by 233 publications

(211 citation statements)

References 64 publications

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“…13 In all studies males outnumbered females. 12,14 In our study M: F ratio was 3:1 and macroscopically solitary lesions were commoner than multiple lesions. The average tumor size was smaller in HCCs arising in a background of cirrhosis when compared to those arising in a normal liver as observed in previous studies.…”

Section: Discussionsupporting

confidence: 44%

Surgical resection for hepatic space occupying lesions: a histopathological analysis

Vani¹,

Kachappilly²,

Geetha³

2017

Int J Res Med Sci

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Background: Hepatic resections are done for both neoplastic and non-neoplastic diseases of liver with malignancies constituting a major share of cases. The objective of this study was to assess the various neoplatic and non-neoplastic lesions in hepatic resection specimens and to categorize the various histopathological types of primary and secondary liver tumors.Methods: The study was conducted in the Department of Pathology, Academy of Medical sciences, Pariyaram. This was a hospital based study which included 79 patients who underwent hepatic resection for space occupying lesions over a period of 5 years from January 2012 to December 2016. IHC was performed in cases with diagnostic dilemma.Results: Of the 79 cases, there were 45 males and 34 females with the age range of 22-85 years. There were 70 neoplastic lesions out of which 11 were benign with 6 cavernous hemangiomas, 3 hepatic adenomas and one each of intraductal papillary neoplasm and mucinous cystic neoplasm. Among the 59 malignant lesions, hepatocellular carcinomas predominated followed by metastatic malignancies and cholangiocarcinomas. Of the metastatic malignancies, adenocarcinoma from gastrointestinal primary was the commonest followed by metastatic gastrointestinal stromal tumor.Conclusions: Liver is a frequent site for many neoplastic and non-neoplastic diseases with malignant neoplasms forming the major bulk. Non-neoplastic lesions like simple liver cysts and focal nodular hyperplasia showed female predominance while benign neoplasms like cavernous hemangioma and hepatic adenomas were seen exclusively in females. Of the malignant liver tumors, hepatocellular carcinoma was the commonest followed by metastatic malignancy, gastrointestinal tract being the commonest source of primary tumor.

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Section: Discussionsupporting

confidence: 44%

Surgical resection for hepatic space occupying lesions: a histopathological analysis

Vani¹,

Kachappilly²,

Geetha³

2017

Int J Res Med Sci

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“…Pathological evaluations of resected specimens were performed by two pathologists with more than 10 years of experience in the field of liver pathology as follows (19)(20)(21)(22):…”

Section: Pathologymentioning

confidence: 99%

Clinical correspondence to hepatocellular carcinoma-related lesions with atypical radiological pattern

Higaki

Midorikawa

Nakashima

et al. 2017

BST

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“…The growth pattern of the cells may be lamellar, trabecular or pseudoglandular. Necrotic foci and blood-filled cavities may be present between the strands of the HCC cells (Kapatkin et al 1992;Schlageter et al 2014).…”

mentioning

confidence: 99%

Immunohistochemical analysis of metastasising hepatocellular carcinomas in dogs

Ciaputa¹,

Bandoch²,

Lewandowska³

et al. 2016

Vet. Med. - Czech

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ABSTRACT:In this study, the immunohistochemical features of primary hepatocellular carcinomas and their metastases in visceral organs, including the lungs, spleen and kidneys were examined using antibodies against carcino-embryonic antigen (CEA) cytokeratin (CK) 7 and 20, CD4, CD8, minichromosome maintenance protein 3 (MCM3), vimentin, and alpha 1 foetoprotein (AFP). In addition, Mallory's connective tissue stain, van Gieson's stain and Gomori methenamine silver stain were used. The study was performed on liver samples collected post mortem from five mixed-breed dogs aged 9-12 years. The tumours were classified according to the World Health Organization Classification of Tumours. Strong expression of MCM3 and AFP was found in the hepatic cancer cells and in the metastases to the lungs, spleen and kidneys. The primary tumours and metastatic foci did not react positively with the anti-CD4, anti-CD8, CEA, CK7 and CK20 antibodies. The connective tissue in the primary tumour and the metastases showed a positive reaction to vimentin. Canine hepatocellular carcinomas that metastasise are highly-malignant well-differentiated tumours that produce AFP and trace amounts of both carcinoembryonic antigen and cytokeratin. Therefore, the metastasis resembles the primary tumour and has a common phenotype and genotype with the primary tumour.

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Histopathology of hepatocellular carcinoma

Cited by 233 publications

References 64 publications

Surgical resection for hepatic space occupying lesions: a histopathological analysis

Surgical resection for hepatic space occupying lesions: a histopathological analysis

Clinical correspondence to hepatocellular carcinoma-related lesions with atypical radiological pattern

Immunohistochemical analysis of metastasising hepatocellular carcinomas in dogs

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