Histopathological spectrum of salivary gland lesions in Ajmer region, Rajasthan, India

Abstract

Background: There is a wide spectrum of salivary gland lesions with morphological and clinical diversity which makes it a difficult task for histopathological interpretation. Tumours of salivary glands are uncommon accounting for 3-10% of the total tumors of head and neck region and less than one percent of all tumours. The aim of this study was to recognize various histomorphological patterns of salivary gland lesions, their frequency, age, gender and site wise distribution.Methods: This study was carried out from June 2015 to May 2018 in the department of Pathology, JLN Medical College and associated Group of Hospitals, Ajmer. Total 121 cases of salivary gland lesions were included. Specimens were processed and stained by Hematoxylin and Eosin stain followed by histopathological examination.Results: Out of total 121 cases, 43.8% were non-neoplastic and 56.2% were neoplastic. In non-neoplastic lesions predominant was chronic sialadenitis (50.9%) followed by mucocele (28.3%) which commonly seen in submandibular gland (47.17%). Among neoplastic cases, 79.4% were benign and 20.6% were malignant lesions. Neoplastic lesions commonly were seen in parotid (75%). Pleomorphic adenoma was the commonest benign tumour (81.4%). Mucoepidermoid carcinoma was the most common malignant salivary tumour. Benign tumours were common in third and fourth decades, whereas malignant tumours were more common in fifth and sixth decades. Male predominance was seen in overall salivary gland lesions.Conclusions: Histopathological examination is mandatory in the diagnosis of salivary gland lesions because of their wide spectrum of histomorphology.

Study of Histopathological Diversity in Salivary Gland Lesions

“…There were eight cases of chronic sialadenitis in the present study which comprises more than 50% of non-neoplastic lesions of salivary glands. This is comparable to study by Omhare et al [14] and Mohan et al [5] In our study, majority of non-neoplastic lesions peak in the age group of 31-40 years and was similar to the study done by Pachori et al [15] and AL-Zamzami et al [16] Male predominance was seen in overall salivary gland lesions in our study which is in accordance with study by Dave et al [6] Chronic sialadenitis may be associated with systemic autoimmune disease. Involvement of both salivary and lacrimal glands is seen in SJogren syndrome (Kerato conjunctivitis sicca also known as dry eyes syndrome).…”

“…Out of this we documented one case each of simple cyst and one case of branchial cyst. This was comparable to the study done by Omhare et al, [14] Mohan et al, [5] and Pachori et al [15] Among the cystic lesions in salivary glands, the most common are lymphoepithelial cysts and other cysts like branchial cleft cyst. Lymphoepithelial cysts can occur in HIV positive patients or as non-specific cysts.…”

“…These were predominantly seen in submandibular glands. This is comparable to the study done by Omhare et al, [14] Pachori et al, [15] AL-Zamzami et al, [16] Kumar et al, [17] and Soni et al [18] Benign cysts of salivary glands comprised 10% of all the lesions. Out of this we documented one case each of simple cyst and one case of branchial cyst.…”

“…In a study by Pachori et al, [15] non-neoplastic lesions of salivary glands were 43.8% and neoplastic lesions were 56.2%. Current study observed that neoplastic lesions (53.9%) outnumbered non-neoplastic lesions (46.1%) which was a similar finding seen in study done by Pachori et al [15] and AL-Zamzami et al [16] In a study by Omhare et al, [14] non-neoplastic lesions were more than the neoplastic lesions. The probable reason for this can be attributed to geographic variation.…”

Histopathological study of salivary gland lesions-an institutional study

“…1 The spectrum of salivary gland lesions is wide and the relative incidence of neoplastic versus non neoplastic lesions is variable in different studies. 2 Salivary gland tumors account for 2% of all human neoplasm and relatively uncommon. 3 Salivary glands tumors are rare with annual incidence <1/100000 inhabitants.…”