Histopathological Observations on the Cochlear Changes in Otosclerosis

Antoli-Candela, F; McGill, Trevor J.; Peron, Didier L.

doi:10.1177/000348947708600617

Cited by 22 publications

(11 citation statements)

References 8 publications

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“… 6,8,38,41,42,44,48,49 Some investigators have observed a localized affect of otosclerotic endosteal involvement of the cochlea with atrophy of the adjacent stria vascularis 34,35,39,40,48,50 or hair cell and nerve fiber loss. 50 Others have observed a generalized affect on stria vascularis atrophy 46 and hair cell loss. 46,48 Both a localized and a generalized affect of otosclerotic endosteal involvement on the sensorineural structures are consistent with the theory that toxic substances generated by the otosclerotic focus diffuse into the perilymphatic fluid.…”

Section: Discussionmentioning

confidence: 99%

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Questioning the Relationship between Cochlear Otosclerosis and Sensorineural Hearing Loss: A Quantitative Evaluation of Cochlear Structures in Cases of Otosclerosis and Review of the Literature

Nelson

Hinojosa

2004

The Laryngoscope

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This study demonstrates a variable amount of degeneration of the cochlear elements in individuals with otosclerotic involvement of the endosteum. The reduction in the population of cochlear elements was not related to the extent and location of endosteal involvement with otosclerosis. These findings suggest that factors that limit the effect of otosclerotic endosteal involvement on the cochlear elements or processes that effect the cochlear elements directly and are independent of bone involvement may be present.

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Section: Discussionmentioning

confidence: 99%

“…Antoli‐Candela et al 46 measured the width of the basilar membrane and the spiral ligament in 17 temporal bones with otosclerotic involvement of the endosteum and 10 normal temporal bones. No difference in the width of the basilar membrane was observed between the two groups.…”

Section: Literature Reviewmentioning

confidence: 99%

Questioning the Relationship between Cochlear Otosclerosis and Sensorineural Hearing Loss: A Quantitative Evaluation of Cochlear Structures in Cases of Otosclerosis and Review of the Literature

Nelson

Hinojosa

2004

The Laryngoscope

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“…postulated that this would be the result of the toxic actions of enzymes released from otosclerotic foci as will be described later in this paper. Another explanation suggests that hyalization of the spiral ligament due to otosclerotic foci is associated with sensorineural hearing loss 27‐29 …”

Section: Literature Studymentioning

confidence: 99%

The aetiology of otosclerosis: a review of the literature

2003

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During the last century, hundreds of studies have been performed to identify factors that are involved in the aetiology of otosclerosis. These studies include a variety of aetiological factors and, although many theories have been postulated, the process of the development of the disease remains unclear. A historical overview and analysis of the literature dealing with the aetiology of otosclerosis is presented. The role of collagen disorders, genetic linkage studies, associations with the HLA system and measles virus infection as causal factors is discussed. From an epidemiological point of view, the disease has an autosomal dominant mode of inheritance. Therefore, since the introduction of new genetic research techniques over the last decades, more studies have been performed to find evidence of a genetic factor that initiates the development of otosclerosis. In this review, we tried to categorize the most prominent studies in sections according to their subjects within the diversity of aetiological factors that have been studied.

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“…Hyalinization of the spiral ligament adjacent to the otosclerotic foci has been shown to be associated with sensorineural hearing loss (Antoli-Candela et al 1977;Gussen 1975;Hinojosa and Marion 1987).…”

Section: Does Otosclerosis Present Only As a Conductive Hearing Loss?mentioning

confidence: 99%