Histopathological Findings In Liver Biopsies And Clinical Correlation At Kano, Nigeria

Samaila, AA; Mohammed, AZ; Borodo, MM; Tijjani, BM

doi:10.4314/smj2.v11i1.12960

Cited by 2 publications

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“…Seventy six cases of HCC found in this study constituted 20.3% of the total. This proportion is less than previous observations reported in Jos (31.3%), Kano (27%), Lagos (33%), and Enugu (24.6%) [28][29][30][31]. This present work provides data on the frequency of the histological sub-types of this tumour.…”

Section: Discussioncontrasting

confidence: 71%

Hepatocellular Carcinoma Sub-types in North-Central Nigeria: A Histological Review of Liver Biopsies

Vhriterhire¹,

Ngbea²,

Ojo³

et al. 2016

BJMMR

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Introduction: Hepatocellular carcinoma (HCC) is the 6 th most common cancer worldwide and a greater burden of this disease is born by the hepatitis B virus (HBV) endemic and resource deficient sub-Sahara Africa. This investigation was carried out to determine the pattern of hepatocellular carcinoma sub-types in north-central Nigeria. Materials and Methods: Archival formalin fixed and paraffin embedded 374 liver biopsy specimen blocks were obtained, sectioned, re-stained and examined histologically. Classification of primary liver cancers was done according to standard World Health Organisation criteria. Results: Chronic HBV infection was found in 219 (58.6%) and cirrhosis in 29 (7.8%) cases. HCC Original Research Articleoccurred in 76 (20.3%) cases with background cirrhosis in 18 (23.7%) of the HCC. The HCC subtypes found were the trabecular 54 (71.1%), acinar 10 (13.2%) and mixed trabecular and acinar 6 (7.9%), clear cell 5 (6.6%) and fibrolamellar 1 (1.3%) respectively. Conclusion: HCC is the most common histologically diagnosed primary liver cell carcinoma with the trabecular subtype as the predominant variant in Nigeria, followed by the pseudoglandular and the mixed types.

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Section: Discussioncontrasting

confidence: 71%

Hepatocellular Carcinoma Sub-types in North-Central Nigeria: A Histological Review of Liver Biopsies

Vhriterhire¹,

Ngbea²,

Ojo³

et al. 2016

BJMMR

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“…The fibrosis/staging done in a total of 39 cases which included chronic hepatitis, primary biliary cirrhosis and NASH showed a decrease in stage in 18 [11] have also reported chronic hepatitis to be the most common histopathological diagnosis in their respective studies (68.3% and 40.5% cases respectively). In this study the clinical diagnosis was confirmed on histopathological examination in 78.5% cases while the histopathological diagnosis did not match the clinical diagnosis in 14.3% cases.…”

Section: Impact Of Length Of Liver Biopsy On Fibrosis/stagingmentioning

confidence: 92%

Impact of the size of liver biopsies on the evaluation of chronic liver disease –a study by artificial sampling

Bashir¹,

Rasool²,

Mateen³

2019

APJHS

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Chronic liver disease is a disease process of the liver that involves progressive destruction and regeneration of the liver parenchyma leading to fibrosis and cirrhosis. We first evaluated the 70 percutaneous liver biopsies from patients with a clinically established diagnosis of chronic hepatitis and chronic liver diseases of various etiologies. All biopsies were obtained through percutaneous approach using 16 F biopsy gun (manufactured by Bard) in adults and 18 F in children. . The mean biopsy size was 1.8cm ± 0.20 and a median size was 2cm. Out of the 70 liver biopsies, a total of 24 (34.2%) liver biopsies were less than 1.5cm in size, and 46(65.7%) were ≥ 1.5cm.

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Histopathological Findings In Liver Biopsies And Clinical Correlation At Kano, Nigeria

Cited by 2 publications

References 0 publications

Hepatocellular Carcinoma Sub-types in North-Central Nigeria: A Histological Review of Liver Biopsies

Hepatocellular Carcinoma Sub-types in North-Central Nigeria: A Histological Review of Liver Biopsies

Impact of the size of liver biopsies on the evaluation of chronic liver disease –a study by artificial sampling

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