Histopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells

Grimm, Kate E.; Barry, Todd; Chizhevsky, Vladislav; Hii, Anselm; Weiss, Lawrence M.; Siddiqi, Imran; Brynes, Russell K.; O’Malley, Dennis P.

doi:10.1038/modpathol.2011.177

Cited by 49 publications

(35 citation statements)

References 17 publications

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“…Of note, however, in a recent paper on the histopathologic features of lymph nodes with increased IgG4-positive plasma cells, granulomas were noted in 3/29 cases (~10%) [12]. It may be of interest to compare the clinical features of IgG4-related disease patients with and without perifollicular granulomas.…”

Section: Discussionmentioning

confidence: 99%

Perifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Perifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis

et al. 2011

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“…[14][15][16] Clinically, there is a marked male predominance in some series, affecting mostly middleaged to elderly individuals. The most common sites include mediastinal, intraabdominal, and axillary lymph nodes.…”

Section: Igg4-related Sclerosing Diseaseassociated Lymphadenopathymentioning

confidence: 99%

Benign lymphadenopathies

Weiss¹,

O’Malley²

2013

Modern Pathology

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“…The disease may manifest as a tumefactive lesion or a rather diffuse infiltrative process, further contributing to a diverse clinical picture. In addition, some organs show a distinct involvement, as for instance lymphadenopathy, periaortitis, or a secondary form of membranous glomerulonephritis (GN) [[11]–[13]].…”

Section: Introductionmentioning

confidence: 99%

IgG4- related disease: an orphan disease with many faces

Pieringer

Parzer

Wöhrer

et al. 2014

Orphanet J Rare Dis

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Immunoglobulin G4- related disease (IgG4-RD) is a rare systemic fibro-inflammatory disorder (ORPHA284264). Although patients have been described more than 100 years ago, the systemic nature of this disease has been recognized in the 21st century only. Type 1 autoimmune pancreatitis is the most frequent manifestation of IgG4-RD. However, IgG4-RD can affect any organ such as salivary glands, orbits, retroperitoneum and many others. Recent research enabled a clear clinical and histopathological description of IgG4-RD. Typically, lymphoplasmacellular inflammation, storiform fibrosis and obliterative phlebitis are found in IgG4-RD biopsies and the tissue invading plasma cells largely produce IgG4. Elevated serum IgG4 levels are found in many but not all patients. Consequently, diagnostic criteria for IgG4-RD have been proposed recently. Treatment is largely based on clinical experience and retrospective case series. Glucocorticoids are the mainstay of therapy, although adjunctive immunosuppressive agents are used in relapsing patients. This review summarizes current knowledge on clinical manifestations, pathophysiology and treatment of IgG4-RD.

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Histopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells

Cited by 49 publications

References 17 publications

Perifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis

Perifollicular granulomatous inflammation in reactive lymph nodes: a possible morphologic marker for IgG4 plasmacytosis

Benign lymphadenopathies

IgG4- related disease: an orphan disease with many faces

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