Histopathological Examination by Lung Biopsy for the Evaluation of Operability and Postoperative Prognosis in Patients With Chronic Thromboembolic Pulmonary Hypertension

Effects of Balloon Pulmonary Angioplasty on Oxygenation in Patients With Chronic Thromboembolic Pulmonary Hypertension – Importance of Intrapulmonary Shunt –

“…30 Indeed, collateral vessels are noted around occluded pulmonary arteries in biopsy samples obtained from CTEPH patients. 31 In the present study, the mean value of intrapulmonary shunt (21.9±7.0%) was higher than the physiological level (5%) in healthy subjects. 25 In the present study, intrapulmonary shunt and mPAP were significantly correlated and changes in both parameters also showed a significant positive correlation, suggesting that elevated PAP reflects increased intrapulmonary shunt.…”

“…They had symptoms of WHO functional class II or more (II/III/IV, 12/11/1 (50/46/4%), respectively). Median duration from symptom onset to first BPA was 13 [6,31] …”

Pulmonary Artery Diameter Predicts Lung Injury After Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension

“…Based on the examination of lung tissue obtained by biopsy, Yamaki, et al have reported that pulmonary hemorrhage after PEA occurs easily in cases with formation of collaterals around the occluded vessels or medial wall thinning by blood flow disruption. 16) However, a method for evaluating the vulnerability of the pulmonary peripheral vascular wall by non-invasive imaging has not been reported. The PA diameter of the central portion we measured in this study may reflect lesion progression in peripheral blood vessels.…”

Effects of Proximal Pulmonary Artery Occlusion on Pulsatile Right Ventricular Afterload in Rats

“…Moreover, chronic changes of RP and CP may be induced by vascular remodeling in patients with chronic thromboembolism. 37, 38 Further investigation is required to evaluate the effects of the humoral factors and vascular remodeling on the parameters of PA impedance.…”