Histopathological Discriminant Criteria between Lichenoid Drug Eruption and Idiopathic Lichen planus: Retrospective Study on Selected Samples

Haute, V. Van den; Antoine, John; Lachapelle, Jean‐Marie

doi:10.1159/000248091

Cited by 122 publications

(64 citation statements)

References 4 publications

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“…Sometimes, there does seem to be a tendency for these oral lesions to be unilateral (Lamey et al, 1995) and erosive (Potts et al, 1987), but these features are by no means invariable. Histology may help; lichenoid lesions may have a more diffuse lymphocytic infiltrate and contain eosinophils and plasma cells, and there may be more colloid bodies than in classic LP, but there are no specific features (Van den Haute et al, 1989), and immunostaining is usually non-contributory, though basal cell cytoplasmic antibodies may be found (Lamey et at., 1995) albeit less reliably than in cutaneous drug reactions (Van Joost, 1974;McOueen and Behan, 1982;Gibson et al, 1986;Watanabe et al, 1991 (Eisen, 1993a)? (4) INFECTIOUS AGENTS Oral LP has been suggested to be related to bacteria such as a Gram-negative anaerobic bacillus (Jacob and Helmbold, 1933) and spirochetes (Lehnhoff, 1948), but this has not been confirmed (Postma, 1937;Fry and Withers, 1969). Lichenoid reactions have been seen in syphilis (Lochner and Pomeranz, 1974), chronic bladder infection (Shelley and Shelley, 1989), and intestinal amebiasis (Wahba-Yahav, 1989), though in both latter cases the lesions appeared to clear following metronidazole treatment.…”

Section: (3) Drugsmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

470

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Section: (3) Drugsmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

470

461

View full text Add to dashboard Cite

show abstract

“…Varying degrees of cytologic atypia is present [18]. Compared to OLP, the malignant transformation rate is reportedly higher in oral lichenoid lesions that do not have all the typical clinical and histologic features of OLP [20]. These studies again emphasize the importance of both clinical and pathologic correlation in making the diagnosis of oral lichen planus.…”

Section: Oral Lichenoid Contact Reactionmentioning

confidence: 83%

Oral Manifestations of Dermatologic Disease: A Focus on Lichenoid Lesions

Müller

2011

Head and Neck Pathol

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Lichenoid changes in the oral mucosa can be encountered in a wide range of lesions with varied etiologies including immune-mediated disorders, reactions to systemic medications and to dental materials. Dysplasia of the oral cavity can exhibit a lichenoid histology, which may mask the potentially cancerous component. Another unusual clinical disease, proliferative verrucous leukoplakia, can often mimic oral lichen planus clinically requiring careful correlation of the clinical and pathologic features.

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“…Oral lichenoid lesions (aLL) resemble oral lichen planus clinically and histologically and have been attributed to various drugs, foodstuff and dental materials. The WHO criteria for lichen planus do not differentiate between the two conditions, although it has been suggested that OLL has a more diffuse lymphocytic infiltrate containing eosinophils with perivascular infiltration (1).…”

Section: Introductionmentioning

confidence: 99%

The Effects Of CO2 Laser On Oral Lichen Planus And Lichenoid Lesions

Kok

Ong

2001

ADUM

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The purpose of this study is to assess the effectiveness of C02 laser in relieving symptoms associated with Oral lichen planus (aLP) and lichenoid lesions (aLL) and the event of healing. Six patients were selected for this study with 13 sites treated. Each lesion was ablated with C02 laser and the wound allowed to heal undisturbed. Prior to treatment, 4 patients had both unprovoked and provoked pain and 2 patients rated for provoked pain only. After laser ablation, five out of six patients treated recorded no pain / 0 pain score. One month post-laser, the treated area was almost the same colour as the surrounding normal mucosa and soft in texture in all but one patient in which there was some fibrosis and residual plaque-like patch. We conclude that the use of C02 laser in the treatment of aLP and aLL shows positive results in relieving symptoms associated with these lesions.

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Histopathological Discriminant Criteria between Lichenoid Drug Eruption and Idiopathic Lichen planus: Retrospective Study on Selected Samples

Cited by 122 publications

References 4 publications

Update On Oral Lichen Planus: Etiopathogenesis and Management

Update On Oral Lichen Planus: Etiopathogenesis and Management

Oral Manifestations of Dermatologic Disease: A Focus on Lichenoid Lesions

The Effects Of CO2 Laser On Oral Lichen Planus And Lichenoid Lesions

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