Histopathological changes of kidney tissue during aging

Kotob, Mohamed H.; Hussein, A. M.; Abd-Elkareem, Mahmoud

doi:10.21608/svu.2021.55868.1092

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…The structural changes of the renal glomeruli in the present work with high dose PGB suggested that it may be followed by deterioration in the physiological functions such as decreased glomerular filtration rate and renal blood flow. The renal tubules showed disrupted their brush border which mainly was followed by a decline in the tubular reabsorption function of the kidney [29].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Ismail

Shaltout

Abdellah

et al. 2022

BMC Pharmacol Toxicol

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Background Pregabalin (PGB) was approved as new anti-epileptic drugs with little information about its teratogenic effect. Aim of the work to evaluate the developmental toxicity of PGB. Materials and methods 60 pregnant albino rats were divided into three groups. PGB (500 mg/kg body weight/day) was given to group II, PGB (1250 mg/kg body weight/day) was given to Group III and no medications were given to group I. The pups were normally delivered. Liver, kidney and heart specimens were prepared for histological, immunohistochemical, and morphometric studies. Results A dose of 500 mg of PGB had minimal toxic effects in the form of mild collagen deposition and moderate positive caspase-3 immunoexpression. PGB dose of 1250 mg/kg induced gross toxic effects in form of degenerated cardiac myofibres, ruptured blood vessels, vacuolations in the renal cortex, fibrosis and strong positive caspase-3 immunoexpression. Conclusion PGB at dose of 500 mg/kg revealed minimal toxic changes. PGB cause embryotoxicity in a dose-dependent manner, as the higher dose induced more degenerative changes.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Ismail

Shaltout

Abdellah

et al. 2022

BMC Pharmacol Toxicol

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“…Negative image analysis was performed using CMEIAS color segmentation to assess the complex color micrographs obtained to give more details 14 – 16 .…”

Section: Methodsmentioning

confidence: 99%

Impact of porous microsponges in minimizing myotoxic side effects of simvastatin

Ali

Abd-Elkareem

Kamel

et al. 2023

Sci Rep

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Simvastatin (SV) is a poorly soluble drug; its oral administration is associated with a significant problem: Myopathy. The present study aims to formulate SV microsponges that have the potential to minimize the myotoxicity accompanying the oral administration of the drug. SV microsponges were prepared by exploiting the emulsion solvent evaporation technique. The % entrapment efficiency (%EE) of the drug approached 82.54 ± 1.27%, the mean particle size of SV microsponges ranged from 53.80 ± 6.35 to 86.03 ± 4.79 µm in diameter, and the % cumulative drug release (%CDR) of SV from microsponges was significantly higher than that from free drug dispersion much more, the specific surface area of the optimized microsponges formulation was found to be 16.6 m2/g revealed the porosity of prepared microsponges. Histological and glycogen histochemical studies in the skeletal muscles of male albino rats revealed that microsponges were safer than free SV in minimizing myotoxicity. These findings were proven by Gene expression of Mitochondrial fusion and fission (Mfn1) & (Fis1) and (Peroxisome proliferator-activated receptor gamma co-activator 1α) PGC-1α. Finally, our study ascertained that SV microsponges significantly decreased the myotoxicity of SV.

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“…Aging is linked to functional decline in the kidneys [ 132 , 133 ]. It has been established that there are numerous changes in the molecular, structural, and morphological levels in the kidney [ 134 , 135 ]. In aging kidneys, there are increased levels of oxidative stress, as reflected by increased lipid peroxidation, mitochondrial dysfunction, and decreased levels of antioxidants, including superoxide dismutase, catalase, and glutathione peroxidase [ 136 , 137 , 138 , 139 ].…”

Section: Miscellaneousmentioning

confidence: 99%

Renal-Protective Roles of Lipoic Acid in Kidney Disease

Kamt

Liu

2023

Nutrients

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The kidney is a crucial organ that eliminates metabolic waste and reabsorbs nutritious elements. It also participates in the regulation of blood pressure, maintenance of electrolyte balance and blood pH homeostasis, as well as erythropoiesis and vitamin D maturation. Due to such a heavy workload, the kidney is an energy-demanding organ and is constantly exposed to endogenous and exogenous insults, leading to the development of either acute kidney injury (AKI) or chronic kidney disease (CKD). Nevertheless, there are no therapeutic managements to treat AKI or CKD effectively. Therefore, novel therapeutic approaches for fighting kidney injury are urgently needed. This review article discusses the role of α-lipoic acid (ALA) in preventing and treating kidney diseases. We focus on various animal models of kidney injury by which the underlying renoprotective mechanisms of ALA have been unraveled. The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron. We highlight the common mechanisms of ALA’s renal protective actions that include decreasing oxidative damage, increasing antioxidant capacities, counteracting inflammation, mitigating renal fibrosis, and attenuating nephron cell death. It is by these mechanisms that ALA achieves its biological function of alleviating kidney injury and improving kidney function. Nevertheless, we also point out that more comprehensive, preclinical, and clinical studies will be needed to make ALA a better therapeutic agent for targeting kidney disorders.

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Histopathological changes of kidney tissue during aging

Cited by 3 publications

References 28 publications

RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Impact of porous microsponges in minimizing myotoxic side effects of simvastatin

Renal-Protective Roles of Lipoic Acid in Kidney Disease

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