Histopathological alterations in lung tissue received as autopsy specimens- a study of 410 cases

Amin, Nirali S.; Shah, Pooja Y; Patel, Ravi G; Khant, Varsha S; Prajapati, Shreedhan G

doi:10.5455/ijmsph.2017.01082016612

Cited by 4 publications

(7 citation statements)

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“…The prevalence of significant histopathological changes in the present study was 84%, which was comparable to the several previous similar studies 1,[6][7][8][9][10][11][12] (Table 4). Male predominance was observed in the present study with 63% of the cases which was comparable to the past similar b a e research.…”

Section: Discussionsupporting

confidence: 91%

“…3,4,6,11,[13][14][15][16] In the present study, the most affected age group was 30-39 years followed by 20-29 years which was comparable to the results of similar studies done by Patel et al, 3 Kurawar and Vasaikar, 4 and Dhruw et al 12 (Table 5). In the present study, the most common histopathological lesion was pneumonia seen in 46% of cases which was comparable to Udayshankar et al, 14 Selvambigai et al, 16 Goswami et al, 17 and Nazish et al 18 Although tuberculosis is prevalent in our India as seen in study done by Amin et al, 6 in the current study, only 4 (4%) cases were found. The reason may be attributed to early diagnosis and better cure rate and, therefore, tuberculosis being primary cause of death in only four cases.…”

Section: Discussionsupporting

confidence: 90%

“…Clinical and autopsy diagnoses have been found to differ significantly in major and minor ways in few studies. 6…”

Section: Study Of Histopathological Spectrum Of Non-neoplastic Lesion...mentioning

confidence: 99%

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Study of histopathological spectrum of non-neoplastic lesions of the lung in autopsy specimen

Guru¹,

Meena²,

Dharmalingam³

et al. 2022

Asian J Med Sci

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Background: Lungs are the major organ involved in infectious and occupational diseases almost secondarily involved in all forms of terminal diseases. Autopsy plays an important role in identifying and understanding the pathology of various respiratory diseases and lung lesions to find out the parenchymal pathology. Aims and Objectives: This study aims to study the histopathological spectrum of non-neoplastic lung lesions in medicolegal autopsy and to assess the frequency of spectrum of lung lesions. Materials and Methods: The present retrospective study was carried out in the Department of Pathology, Shyam Shah Medical College, Rewa, M.P., for a period of 18 months from July 2020 to January 2022. All 98 consecutive specimens of medicolegal autopsy were included with age from newborn to 70 years irrespective of gender and cause of death. The results were analyzed based on gross and microscopic findings. Results: Among the 98 cases studied, 82 cases (84%) were of diseased and 16 cases (16%) were of non-diseased lung. The most common age group affected was 30–39 years with 30% of affected cases followed by 20–29 years with 21% of affected cases. Among 82 cases, the most common pulmonary lesion was pneumonia in 46% (45/98) of the total cases followed by congestion and edema seen in 22% (21/98) of the cases. Conclusion: Histopathological study of lung autopsy helps in providing information for clinical diagnosis of non-neoplastic lung lesions that act as a tool for better clinical assessment and help to establish a correct prophylactic measure. The histopathological examination (HPE) helps in establishing the final cause of death. The HPE helps in establishing the final cause of death. Therefore, autopsy study is very helpful in refining the vision and diagnostic setup for better evaluation.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

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Study of histopathological spectrum of non-neoplastic lesions of the lung in autopsy specimen

Guru¹,

Meena²,

Dharmalingam³

et al. 2022

Asian J Med Sci

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“…Similar findings were observed in study done by Nirali et al . [ 11 ] and Udayshankar et al . [ 1 ] In our study, emphysema cases were 15.8% which was almost exactly comparable to Selvambigai et al .…”

Section: Discussionmentioning

confidence: 99%

Autopsy study of spectrum of lung lesions in Tertiary care hospital

Goswami

Khandkar

2021

Journal of Family Medicine and Primary Care

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Background: Inflammation, Infections, occupational diseases and neoplastic lesions are common in lungs. In Autopsy internal organs including lungs are studied to decide cause of death and figure out prevalence of various lung lesions. So, prophylactic prevention plan can be prepared for prevention of various lung lesions induced mortality and reducing need for invasive biopsy as well. Aim & objective: To find out frequency of various lung lesions in relation to age and sex and analyze histopathological spectrum of lung lesions. Material & Methods: Non interventional, record based cross sectional, retrospective autopsy study was done on 139 cases of lung autopsy samples at department of pathology of tertiary care hospital, Bhavnagar, Gujarat for 2 years on samples received from January 2016 to January 2018. Lungs were fixed in 10% formalin & processed. Paraffin wax embedding was done & sections stained with H&E stain. Gross and microscopic examination of samples done and diagnosis was done. All findings were recorded and tabulated. Conclusion: Pneumonia is most common observed pathological lung lesion in our study which suggest that infections of lungs are common cause for mortality. Therefore, we suggest effective implementation of measures to prevent hospital acquired pneumonia may reduce mortality. Smoking was associated in nearly 70% patients. Autopsy study of such lung lesions can provide vision to plan preventive strategy to reduce mortality due to lung pathology.

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“…In 1,11 In our study male (77.9%) were more commonly affected than female which was comparable with study done by Bal et al, Amin et al and Sweta et al which showed 80%, 79.5% and 88% of male respectively. 3,10,13 The terminal events which include congestion/ oedema/changes in interstitium/pulmonary haemorrhage were one of the most common findings in this study and were similar to Chauhan et al, Rupali et al and Puneet et al 11,14,15 The results of this study show that among the pulmonary diseases, pneumonia ( 3 (1.0%) cases of malignant lesion were identified among which 1 case was of small cell carcinoma and 2 cases were of adenocarcinoma, one of which showed metastatic deposits in heart. Findings of our study was in concordance with studies done by Chauhan et al, Bal et al and Amin et al which showed 2.08%, 2% and 1.7% malignant lesions respectively.…”

Section: Discussionmentioning

confidence: 99%

Autopsy: a value to primordial and primary prevention for lung diseases

Rana

Kaushik²,

Verma³

et al. 2022

Int J Res Med Sci

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Background: Lung disorders spectrums include congestion, oedema, various inflammatory lesions, chronic obstructive pulmonary diseases and neoplastic lesions. The clinical and radiological findings in respiratory diseases are nonspecific and therefore a histopathological study is essential. Autopsies are necessary to establish cause of death of the person with help of antemortem history and investigations to rule out lung lesions. Aims and objectives were to identify the histopathological spectrum of lung disease and frequency of various lung pathologies in respect to age and sex.Methods: The retrospective study of 285 lung autopsy specimens received were fixed and processed. Routine paraffin sectioning was done followed by hematoxylene and eosin (H and E) staining. Relevant clinical and postmortem findings, gross and microscopic examination findings were recorded.Results: Most common lung pathology found was Edema and congestion in 149 cases (52.2%), pneumonia in 87 cases (30.5%) followed by tuberculosis in 33 cases (11.5%). Out of total 285 cases, 222 (77.9%) were males and 63 cases (22.2%) were females. The male to female ratio was 3.5:1. Maximum numbers of cases, in age group of 31-45 years were 108 cases (37.89%) followed by in age group 46-60 years were 90 cases (31.57%) followed by age group of 16-30 years 15.8%.Conclusions: Advances in diagnostic technology have not reduced the value of autopsy for the study and evaluation of the disease process. It has become crucial for adopting correct prophylactic actions for primordial and primary prevention of pulmonary dysfunctions.

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Histopathological alterations in lung tissue received as autopsy specimens- a study of 410 cases

Cited by 4 publications

References 0 publications

Study of histopathological spectrum of non-neoplastic lesions of the lung in autopsy specimen

Study of histopathological spectrum of non-neoplastic lesions of the lung in autopsy specimen

Autopsy study of spectrum of lung lesions in Tertiary care hospital

Autopsy: a value to primordial and primary prevention for lung diseases

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