Histopathologic Study of Hidradenitis Suppurativa Following Long-Pulsed 1064-nm Nd:YAG Laser Treatment

Abstract

To assess clinical and histopathologic changes occurring after long-pulsed 1064-nm Nd:YAG laser treatment of hidradenitis suppurativa (HS). Design: Prospective, controlled clinical and histologic study of patients with Hurley stage II HS disease.

Efficacy of Nd:YAG Laser for the Treatment of Hidradenitis Suppurativa

“…The long-pulsed neodymium:yttrium-aluminium-garnet (Nd:YAG) laser is a device that has traditionally been used for hair removal, but has recently shown promise in clearing old lesions of HS and preventing new eruptions. In accordance with studies in the current literature, we hypothesize that the Nd:YAG laser will significantly improve subjects with hidradenitis suppurativa compared to standard, uninvasive treatment with topical antibiotics [1,2]. Study aims include: to treat subjects with hidradenitis suppurativa with Nd:YAG laser therapy once monthly for 3 consecutive months, with a one month followup; to compare the effectiveness of Nd:YAG treatment on one side of the subject (e.g., right) to treatment with topical antibiotics on the subject's other side (e.g., left); to assess treatment response using a visual analogue scale; to assess subject satisfaction with treatment using a questionnaire; and to photodocument treatment response at each visit.…”

Efficacy of Nd:YAG Laser for the Treatment of Hidradenitis Suppurativa

“…The long-pulsed neodymium:yttrium-aluminium-garnet (Nd:YAG) laser is a device that has traditionally been used for hair removal, but has recently shown promise in clearing old lesions of HS and preventing new eruptions. In accordance with studies in the current literature, we hypothesize that the Nd:YAG laser will significantly improve subjects with hidradenitis suppurativa compared to standard, uninvasive treatment with topical antibiotics [1,2]. Study aims include: to treat subjects with hidradenitis suppurativa with Nd:YAG laser therapy once monthly for 3 consecutive months, with a one month followup; to compare the effectiveness of Nd:YAG treatment on one side of the subject (e.g., right) to treatment with topical antibiotics on the subject's other side (e.g., left); to assess treatment response using a visual analogue scale; to assess subject satisfaction with treatment using a questionnaire; and to photodocument treatment response at each visit.…”

Surgical Treatment in Hidradenitis Suppurativa

“…This also reiterates the role of dysregulation of the follicular milieu in the pathogenesis of HS [75]. Histopathological evaluation of lesions treated with Nd-YAG have revealed follicular-oriented lymphocytic infiltrates posttreatment, which confirms the follicular origin of the disease and the role of Nd-YAG lasers in curbing disease progression [74,76].…”

Severe Hidradenitis Suppurative in an HIV-Positive Male: Use of Multiple Treatment Modalities, Including Tumor Necrosis Factor Blockade

“…The Nd:YAG laser is a novel treatment option that causes the destruction of the follicular unit and abscess. 11 In our patient, this approach had no impact on scar tissue, but considerable relief of tenderness was observed.…”

Efficacy of Nd:YAG Laser for the Treatment of Hidradenitis Suppurativa

“…The long-pulsed neodymium:yttrium-aluminium-garnet (Nd:YAG) laser is a device that has traditionally been used for hair removal, but has recently shown promise in clearing old lesions of HS and preventing new eruptions. In accordance with studies in the current literature, we hypothesize that the Nd:YAG laser will significantly improve subjects with hidradenitis suppurativa compared to standard, uninvasive treatment with topical antibiotics [1,2]. Study aims include: to treat subjects with hidradenitis suppurativa with Nd:YAG laser therapy once monthly for 3 consecutive months, with a one month followup; to compare the effectiveness of Nd:YAG treatment on one side of the subject (e.g., right) to treatment with topical antibiotics on the subject's other side (e.g., left); to assess treatment response using a visual analogue scale; to assess subject satisfaction with treatment using a questionnaire; and to photodocument treatment response at each visit.…”

Surgical Treatment in Hidradenitis Suppurativa

“…This also reiterates the role of dysregulation of the follicular milieu in the pathogenesis of HS [75]. Histopathological evaluation of lesions treated with Nd-YAG have revealed follicular-oriented lymphocytic infiltrates posttreatment, which confirms the follicular origin of the disease and the role of Nd-YAG lasers in curbing disease progression [74,76].…”

Severe Hidradenitis Suppurative in an HIV-Positive Male: Use of Multiple Treatment Modalities, Including Tumor Necrosis Factor Blockade

“…The Nd:YAG laser is a novel treatment option that causes the destruction of the follicular unit and abscess. 11 In our patient, this approach had no impact on scar tissue, but considerable relief of tenderness was observed.…”

Efficacy of Nd:YAG Laser for the Treatment of Hidradenitis Suppurativa

“…The long-pulsed neodymium:yttrium-aluminium-garnet (Nd:YAG) laser is a device that has traditionally been used for hair removal, but has recently shown promise in clearing old lesions of HS and preventing new eruptions. In accordance with studies in the current literature, we hypothesize that the Nd:YAG laser will significantly improve subjects with hidradenitis suppurativa compared to standard, uninvasive treatment with topical antibiotics [1,2]. Study aims include: to treat subjects with hidradenitis suppurativa with Nd:YAG laser therapy once monthly for 3 consecutive months, with a one month followup; to compare the effectiveness of Nd:YAG treatment on one side of the subject (e.g., right) to treatment with topical antibiotics on the subject's other side (e.g., left); to assess treatment response using a visual analogue scale; to assess subject satisfaction with treatment using a questionnaire; and to photodocument treatment response at each visit.…”

Surgical Treatment in Hidradenitis Suppurativa

“…This also reiterates the role of dysregulation of the follicular milieu in the pathogenesis of HS [75]. Histopathological evaluation of lesions treated with Nd-YAG have revealed follicular-oriented lymphocytic infiltrates posttreatment, which confirms the follicular origin of the disease and the role of Nd-YAG lasers in curbing disease progression [74,76].…”

Severe Hidradenitis Suppurative in an HIV-Positive Male: Use of Multiple Treatment Modalities, Including Tumor Necrosis Factor Blockade

“…The Nd:YAG laser is a novel treatment option that causes the destruction of the follicular unit and abscess. 11 In our patient, this approach had no impact on scar tissue, but considerable relief of tenderness was observed.…”