Histopathologic Evaluation of Griseofulvin in Microsporum Audouini Infections

Burgoon, Carroll F.

doi:10.1001/archderm.1960.03730050080014

Cited by 16 publications

(3 citation statements)

References 14 publications

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“…In support of his postulate, McNall cited the antimitotic colchicine-like effect reported for griseofulvin in rat and bean root cells Walpole, 1958, 1960). Mitotic interference was not observed, however, in hair roots of human scalp (Burgoon et al, 1960).…”

Section: Discussionmentioning

confidence: 74%

Antibiotic Action of Griseofulvin on Dermatophytes

1965

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The concentrations of griseofulvin required to inhibit growth and to produce the characteristic morphological distortions were determined for dermatophytes (highly sensitive), fungal plant pathogens (moderately sensitive), filamentous nonpathogenic fungi (poorly sensitive), and for yeasts and Escherichia coli (insensitive). Addition of griseofulvin to small inocula of the dermatophytes Microsporum gypseum and Trichophyton mentagrophytes produced complete and apparently permanent growth inhibition. If the antibiotic was added to actively growing cultures, the inhibition was only temporary, even with the most sensitive dermatophytes. During growth inhibition, griseofulvin temporarily halted the net synthesis of protein and nucleic acids, and of the amino acid and nucleotide pools. It decreased substantially the incorporation of C14-uridine or C'4-thymidine into nucleic acids of M. gypseum, but not that of C'4-leucine or C14-valine into protein. With a less sensitive culture, T. mentagrophytes x8, the uptake of uridine was inhibited only to a slight extent; the incorporation of leucine was unaffected. A partial protective effect of purine nucleotides against growth inhibition by griseofulvin was observed with one strain of T. mentagrophytes, but not with another strain or with M. gypseum.

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Section: Discussionmentioning

confidence: 74%

Antibiotic Action of Griseofulvin on Dermatophytes

1965

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“…When lettuce and oat plants were subjected to the antibiotic, both roots and shoots were stunted (BRIAN, 1951). At 5 !1-gfml, griseofulvin caused the roots of wheat seedlings to become stunted and swollen just behind the tip (STOKES, 1954).Griseofulvin administered orally to humans produced essentially no side effects (ROTH and BLANK, 1960b;RoTH et al, 1959b;BURGOON et al, 1960). GOLDMAN et al ( 1960) observed that the antibiotic had no effect on skin tumors.…”

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confidence: 99%

Antibiotics

1967

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AII rights, especially that of tnmslation into foreign languages, reserved. It is also forbidden to reproduce this book, either whole DedicationFor most areas of scientific pursuit, there is usually that rare investigator who has the imagination to conceive ideas, who has faith in his visions, and who has the ability to critically test his concepts in the laboratory. Almost invariably, this scientist also inspires younger men to enthusiastically enter into his research program. To him should go the accolades and the recognitions of the esteem in which he is held. As only a small part of this esteem, we wish to dedicate these books to Professor SELMAN A. W AKSMAN in appreciation of his leadership and contributions in all facets of antibiotic research. PrefaceThe idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a bibliography on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving forward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master.That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and biosynthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known. Yet, such an approach would not entirely serve the purpose we projected, for it would not encompass all of the information available in these fields of antibiotic investigations and blind searches for the original literature would still have to be made. We therefore chose to include any and all antibiotics about which some pertinent information had been published. It was obvious even at the start that such a compilation, integration, and analysis of information could never be complete unless scientific investigations ceased at the moment the last manuscript was submitted-an end that was neither desirable nor possible. An addendum was therefore included at the end of the volume and left open for the addition of new information until the last pages of the regular articles had been printed.The original concept has also been further expanded as the authors of several papers found it advisable to elaborate on their subject. Some of the articles included discussions...

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“…Diese tie re x p e rim cn telle n B efunde en tsp rech en den th e ra p e u tisc h en E rgebnissen am M enschen, wo bei F ällen von T in e a corporis, T inea cap itis u n d T in ea pedis n a c h m ehrw öchiger G ri-B eh an d lu n g , o ft nach B esserung d e r m ak ro sk o p isch en V erän d eru n g en , no ch Pilze an der e rk ra n k te n Stelle nachgew iesen w u rd en [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20]. D ie T h erap ieresisten z vo n H a u tste lle n m it dick er H o rn sc h ic h t, sowie diejenige d er O nychom ykosen k ö n n te auch a u f diese W eise e rk lä rt w erden.…”

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Zur Wirkung von lokal (epicutan) appliziertem Griseofulvin auf die experimentelle Meerschweinchen-Trichophytie

Frey¹,

Geleick²

1960

Dermatology

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Histopathologic Evaluation of Griseofulvin in Microsporum Audouini Infections

Cited by 16 publications

References 14 publications

Antibiotic Action of Griseofulvin on Dermatophytes

Antibiotic Action of Griseofulvin on Dermatophytes

Antibiotics

Zur Wirkung von lokal (epicutan) appliziertem Griseofulvin auf die experimentelle Meerschweinchen-Trichophytie

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