Histopathologic Changes in the Temporal Bone Resulting From Measles Infection

Idiopathic Sudden Sensorineural Hearing Loss: Speech Intelligibility Deficits Following Threshold Recovery

“…Several studies examined the histopathological correlates of irreversible SSNHL (e.g., Schuknecht et al 1962Schuknecht et al , 1973Schuknecht & Donovan 1986;Merchant et al 2005;. There was no histological evidence of membrane breaks; however, most ears showed damage similar to that observed in viral infections (e.g., mumps, rubella; Merchant & Nadol 2010), including atrophy of the organ of Corti and stria vascularis in the basal turn and loss of auditory nerve fibers (Bordley & Kapur 1977;Gussen 1981;Davis & Johnsson 1983). The basal turn focus of these permanent lesions is consistent with the HF bias of the irreversible cases of SSNHL.…”

Morbilliviruses and human disease

“…However, whether this occurs directly or indirectly is unclear [98]. Pathological changes have been reported in four individuals with severe necrotizing otitis media who died due to secondary bronchopneumonia, indicating that the virus may directly infect the middle ear [99]. Moreover, multi-nucleated cells were detected in one of these cases, although neither MV antigen nor RNA was detected.…”

Idiopathic Sudden Sensorineural Hearing Loss: Temporal Bone Histopathologic Study

“…About 25% of patients have spontaneous recovery, 50% have partial return of hearing, and 25% have no recovery of hearing. ' The cause of this disorder is not known, but histopathologic studies of human temporal bones have suggested viral, [2][3][4][5][6] vascular, 7 • 8 and immunologie 9 causes and a theory of ruptured inner ear membranes. 10 • 1 '…”