2009
DOI: 10.1038/nature07829
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The human body is composed of diverse cell types with distinct functions. While it is known that lineage specification depends on cell specific gene expression, which in turn is driven by promoters, enhancers, insulators and other cis-regulatory DNA sequences for each gene1–3, the relative roles of these regulatory elements in this process is not clear. We have previously developed a chromatin immunoprecipitation-based microarray method (ChIP-chip) to locate promoters, enhancers, and insulators in the human ge… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

152
2,156
6
6

Year Published

2010
2010
2018
2018

Publication Types

Select...
6
4

Relationship

0
10

Authors

Journals

citations
Cited by 2,203 publications
(2,320 citation statements)
references
References 27 publications
152
2,156
6
6
Order By: Relevance
“…trans -eVariants were more enriched than cis -eVariants at matched FDR (Wilcoxon rank sum test, promoter: P ≤ 4.6 ×10 −7 ; enhancer: P ≤ 2.2 ×10 −16 ). Stronger effect sizes are needed to detect trans -eVariants at the same FDR, but even comparing to a matched number of the strongest cis -eVariants, we observed greater enrichment in enhancer (but not promoter) regions among trans -eVariants, consistent with greater tissue-specificity of enhancer activity and trans -eVariants 31 (Fig. 2c).…”
Section: Functional Characterization Of Trans-eqtlsmentioning
confidence: 55%
“…trans -eVariants were more enriched than cis -eVariants at matched FDR (Wilcoxon rank sum test, promoter: P ≤ 4.6 ×10 −7 ; enhancer: P ≤ 2.2 ×10 −16 ). Stronger effect sizes are needed to detect trans -eVariants at the same FDR, but even comparing to a matched number of the strongest cis -eVariants, we observed greater enrichment in enhancer (but not promoter) regions among trans -eVariants, consistent with greater tissue-specificity of enhancer activity and trans -eVariants 31 (Fig. 2c).…”
Section: Functional Characterization Of Trans-eqtlsmentioning
confidence: 55%
“…H3K4me1 also broadly marks distal regulatory regions. In contrast, H3K27me3 has been proposed to accumulate on silent but poised enhancers and promoters of repressed genes (Heintzman et al , 2007, 2009; Rada‐Iglesias et al , 2011). Therefore, enrichment for H3K4me1, H3K4me3, H3K27ac, and H3K27me3 at the Esrrb and Nanog enhancers/promoters was determined in the three ESC populations.…”
Section: Resultsmentioning
confidence: 99%
“…Nonetheless, the correlation of intergenic H3K9ac sites with multiple promoter and enhancer marks has been used to infer that H3K9ac can denote active enhancers as well as bivalent promoters in stem cells [10,11]. Moreover, a combination of H3K4me1 and H3K27ac can serve as a readout of active enhancers [1,2,12,13]. The regulation of enhancer chromatin state thus interjects specific gene expression programs that govern the potential for cellular differentiation.…”
Section: Introductionmentioning
confidence: 99%