Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases

Abstract

Fourteen miRNAs could be linked to the expression of eight HDACs influencing the α-(1,6)-fucosyltransferase, polycystin-2 and the fibroblast-growth-factor 2 pathways. Focusing on the complex linkage of miRNA and HDAC expression could give deeper insights in new 'druggable' targets and might provide possible novel therapeutic approaches in future.

Genome-Wide Association Studies and Epigenome-Wide Association Studies Go Together in Cancer Control

“…Compared with genomic changes, which are static, epigenetic changes are dynamic. Current literature supports the idea that interindividual epigenetic alterations contribute to disease development, including carcinogenesis [119]. Similar to GWAS, EWAS focus on common variations in the population -rather than on rare alterations in the epigenome -and might be more powerful in identifying risk-associated biomarkers.…”

Regulation of MicroRNAs by Natural Products and Bioactive Compounds Obtained From Common Medicinal Plants: Novel Strategy in Cancer Therapy

“…In case of any of these situations, they will lead to the loss of control in cell growth and division resulting in development of cancer proliferation and metastasis. 13,14 In the recent years, scientific researches related to evaluate changes and alterations in the expression patterns of miRNAs have gained significant attention, particularly recognizing miRNA biomarkers as an indicator in various cancer cases, owing to their changeable expression levels depending on the cancerous conditions. 7,8 Some of them such as miR-10b, miR-21, miR-27a, miR-155, miR-373, miR-424-5p, miR-520c have been identified as oncogenic miRNAs that found overexpressed in various cancers, whereas, the others including miR-15a, miR-16-1, miR-34, miR-126, miR-150, miR-183, miR-203, miR-206, miR-335, miR-495 have been identified as tumor suppressor miRNAs that found down expressed in the cancers compared to normal cells.…”

“…7,8 Some of them such as miR-10b, miR-21, miR-27a, miR-155, miR-373, miR-424-5p, miR-520c have been identified as oncogenic miRNAs that found overexpressed in various cancers, whereas, the others including miR-15a, miR-16-1, miR-34, miR-126, miR-150, miR-183, miR-203, miR-206, miR-335, miR-495 have been identified as tumor suppressor miRNAs that found down expressed in the cancers compared to normal cells. [13][14][15] Despite the fact that many genetic and epigenetic alterations in the coding miRNA genes were determined, many of them are not tissue specific miRNA in diagnosis and prognosis of cancer, not suitable for clinical applications as well. Therefore, further researches should be focused on discovering cancer-related miRNAs which play significant roles in carcinogenic pathways.…”

“…[5][6][7][8] [13][14][15][16][17][18] The miRNAs regulated by a selection of important anticancer natural products and compounds that obtained from main known medicinal plants are presented in Table 1. As summarized in Table 1, recent studies and clinical trials which are aimed to find novel targets for the treatment of multiple types of cancers, have emphasized the importance of the consumption of natural agents-rich diet, including curcumin, berberine, alkaloids, mitomycin C, resveratrol, camptothecin, topotecan, trabectedin, matrine, honokiol, isoflovones, indole-3-carbinol, sulforaphane, water soluble vitamins, diallyl disulfide, 3,3'-diindolylmethane, epigallocatechin-3-gallate and hesperidin, etc., additionally syntheses of natural products by the liposome or nanoparticle formulations assays.…”

Epigenetic Regulation of Gene Expression in Head and Neck Squamous Cell Carcinoma: Therapeutic Perspectives

“…Участие микроРНК в регуляции экспрессии HDAC было описано в контексте различных онкологических заболеваний [47]. В ряде работ было показано, что в клетках ОГШ уровень ацетилирования белков-гистонов существенно ниже по сравнению с клетками нормального эпителия, что свидетельствует о патоло-гически высокой активности ферментов деацетилаз [48].…”