volume 6, issue 1, Pe1000737 2010
DOI: 10.1371/journal.ppat.1000737
View full text
Sign up to set email alerts

Abstract: The apparent paucity of molecular factors of transcriptional control in the genomes of Plasmodium parasites raises many questions about the mechanisms of life cycle regulation in these malaria parasites. Epigenetic regulation has been suggested to play a major role in the stage specific gene expression during the Plasmodium life cycle. To address some of these questions, we analyzed global transcriptional responses of Plasmodium falciparum to a potent inhibitor of histone deacetylase activities (HDAC). The inh…

Expand abstract