2016
DOI: 10.2217/epi.15.118
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Abstract: HDAC inhibitors (HDACIs) are anticancer agents being developed in preclinical and clinical settings due to their capacity to modulate gene expression involved in cell growth, differentiation and apoptosis, through modification of both chromatin histone and nonhistone proteins. Most HDACIs in clinical development have cytotoxic or cytostatic properties and their direct inhibitory effects on tumor cells are well documented. Numerous studies have revealed that HDACIs have potent immunomodulatory activity in tumor… Show more

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Cited by 58 publications
(54 citation statements)
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“…Recent reports suggest that HDAC inhibition alters the cytokine release and may change the function of innate immune cell infiltrates in the tumor microenvironment (6,8,12,35). Interestingly, correlative studies performed in breast cancer patients receiving entinostat showed a decrease in both monocytic and granulocytic MDSCs (35).…”
Section: Discussionmentioning
confidence: 99%
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“…Recent reports suggest that HDAC inhibition alters the cytokine release and may change the function of innate immune cell infiltrates in the tumor microenvironment (6,8,12,35). Interestingly, correlative studies performed in breast cancer patients receiving entinostat showed a decrease in both monocytic and granulocytic MDSCs (35).…”
Section: Discussionmentioning
confidence: 99%
“…MDSC are well known inhibitors of T cell proliferation and activity. Recent reports suggest that HDAC may play a role in this suppressive function (6,10,12,22,24,26,28). Thus, our study shows that entinostat treatment has an inhibitory effect on PMN- and M-MDSC suppressive function both in vivo and in vitro – either with cells directly from the TME or using an MDSC-like cell line.…”
Section: Discussionmentioning
confidence: 99%
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“…Elevated expression of HDACs are evident in advanced malignancy, where inhibitors (HDACis) antagonize tumor growth (2,3) antagonize tumor growth (2,3), augment chemotherapy (4-7), reverse chemoresistance (3,8,9), attenuate metastasis, halt epithelial-mesenchymal transition (10)(11)(12) and block tumor immune evasion (13,14). With the overwhelming surge of HDACis being sought worldwide for nearly every type of cancer (e.g.…”
mentioning
confidence: 99%