Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
50
1

Year Published

2015
2015
2023
2023

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 65 publications
(53 citation statements)
references
References 37 publications
2
50
1
Order By: Relevance
“…Furthermore, the overexpression of HDAC6 causes a de-acetylation of α-tubulin, resulting in damaged primary cilia and impaired mechanically driven osteogenesis [27]. Conversely, HDAC4, -5, -6, -7, and -8 have been described to bind Runx2 and thus interfere with its transcriptional activity [23][24][25][26]. Thus, the decrease in HDAC9 in combination with the increased expression of HDAC1, -2, -3, and -6 in our rhTGF-β 1 -treated hOBs could be responsible for the observed loss of function.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, the overexpression of HDAC6 causes a de-acetylation of α-tubulin, resulting in damaged primary cilia and impaired mechanically driven osteogenesis [27]. Conversely, HDAC4, -5, -6, -7, and -8 have been described to bind Runx2 and thus interfere with its transcriptional activity [23][24][25][26]. Thus, the decrease in HDAC9 in combination with the increased expression of HDAC1, -2, -3, and -6 in our rhTGF-β 1 -treated hOBs could be responsible for the observed loss of function.…”
Section: Discussionmentioning
confidence: 99%
“…Runx2 expression is shown to be inhibited by HDAC1 and HDAC3 [20][21][22]. Runx2 transcriptional activity is reduced by the binding of class II HDACs (HDAC4, -5, -6, and -7) to Runx2 [23][24][25][26]. In addition, enhanced expression of HDAC6 causes deacetylation of α-tubulin, causing a shortening and distortion of the cells primary cilia (mechanosensors) and thus impairing mechanically driven osteogenesis [27].…”
Section: Introductionmentioning
confidence: 99%
“…Each group underwent either sham surgery or bilateral ovariectomy via the dorsal approach (Xu et al., 2016). Three months after surgery, BMSCs in the femur and tibia were harvested from both sham and OVX rats (Fu et al., 2014). Fifteen‐month‐old male Sprague‐Dawley rats were randomly divided into three groups.…”
Section: Methodsmentioning
confidence: 99%
“…BMSCs from young rats (3 months old), middle‐aged rats (12 months old) and aged rats (18 months old) were harvested from the femur and tibia as previously described in an earlier study (Fu et al., 2014). Briefly, bone marrow was flushed with α‐MEM by an 18‐gauge sterile needle inserted into the medullary cavity.…”
Section: Methodsmentioning
confidence: 99%
“…HDACs, key factors for bone formation [67] (see above), deacetylate N-terminal tails of histones and RUNX2 [68], thus mediating transcriptional repression and stability respectively. HDAC3, HDAC7, and HDAC8 interact with RUNX2 and act as a co-repressor of osteoblast-specific genes, such as OCN , BSP , and RUNX2 , in mouse MC3T3-E1 and C2C12 cell lines, and rat BMSCs [69,70,71]. Osteochondral lineage specific HDAC3 knockout mice show severe reductions in trabecular bone, bone formation rates, and osteoblast numbers, accompanied with increased MAT [72].…”
Section: Epigenetics In Osteo-adipogenesismentioning
confidence: 99%