volume 285, issue 10, P7187-7196 2010
DOI: 10.1074/jbc.m109.061861
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I-Lu Lai, Tung-Ping Lin, Ya-Li Yao, Ching-Yi Lin, Mei-Ju Hsieh, Wen-Ming Yang

Abstract: HDAC10 belongs to the class II histone deacetylase family; however, its functions remain enigmatic. We report here that the HDAC10 protein complex contained deacetylated chaperone protein hsc70, and HDAC10 relieved repression of melanogenesis by decreasing the repressional activity of two transcriptional regulators, paired box protein 3 (Pax3) and KRAB-associated protein 1 (KAP1). HDAC10 physically interacted with Pax3 and KAP1 in a ternary complex and maintained Pax3 and KAP1 in a deacetylated state. Deacety…

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