Histology and Immunohistochemistry of the Cardiac Ventricular Structure in the Green Turtle<i>(Chelonia mydas)</i>

Braz, Janine Karla França da Silva; Freitas, Maria Luiza Pontes de França; Magalhães, Marcela dos Santos; Oliveira, Moacir Franco de; Costa, Miriam S.M.O.; Resende, N. S.; Clebis, Naianne Kelly; Silva, N. B.; Moura, Carlos Eduardo Bezerra de

doi:10.1111/ahe.12195

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…In our embryonic crocodiles, alligators and caimans, the cartilage elements have not fused, which was also the case in one juvenile crocodile of approximately 60 cm overall length. Other reptiles [52], terrapin [53,54] and turtle [20] present with cartilage prongs. We hypothesize that the elements, being aorta-bound, most likely develop from the left NC stream.…”

Section: Cartilage In the Oft Cushionsmentioning

confidence: 99%

Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves

Poelmann

Groot

Goerdajal

et al. 2021

JCDD

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Background: The outflow tract of crocodilians resembles that of birds and mammals as ventricular septation is complete. The arterial anatomy, however, presents with a pulmonary trunk originating from the right ventricular cavum, and two aortas originating from either the right or left ventricular cavity. Mixing of blood in crocodilians cannot occur at the ventricular level as in other reptiles but instead takes place at the aortic root level by a shunt, the foramen of Panizza, the opening of which is guarded by two facing semilunar leaflets of both bicuspid aortic valves. Methods: Developmental stages of Alligator mississipiensis, Crocodilus niloticus and Caiman latirostris were studied histologically. Results and Conclusions: The outflow tract septation complex can be divided into two components. The aorto-pulmonary septum divides the pulmonary trunk from both aortas, whereas the interaortic septum divides the systemic from the visceral aorta. Neural crest cells are most likely involved in the formation of both components. Remodeling of the endocardial cushions and both septa results in the formation of bicuspid valves in all three arterial trunks. The foramen of Panizza originates intracardially as a channel in the septal endocardial cushion.

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Section: Cartilage In the Oft Cushionsmentioning

confidence: 99%

Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves

Poelmann

Groot

Goerdajal

et al. 2021

JCDD

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“…The normal endocardium has three sublayers: ( i ) endothelium which consist of simple squamous epithelium and subendothelial connective tissue (inner portion that lines all heart cavities); ( ii ) fibroelastic connective tissue that intertwined with thin smooth muscle cells (middle layer); ( iii ) subendocardial layer joining the endocardium to myocardium by loose connective tissue (deeper layer) [ 16 ].…”

Section: ⧉ Key Players In Efe Assessmentmentioning

confidence: 99%

Endocardial fibroelastosis and dilated cardiomyopathy – the past and future of the interface between histology and genetics

Luca

Lozneanu

Miron³

et al. 2021

Rom J Morphol Embryol

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Endocardial fibroelastosis (EFE) signifies the pathological process by which collagen and elastin are focally or diffuse deposited in the endocardium of the left ventricle. The new layer causes left ventricular dysfunction sometimes with fulminant progression to heart failure. EFE is a major component in many congenital heart abnormalities but can also occur in the absence of heart malformations, either as a primary process or in response to cardiac injury. The endothelial-mesenchymal transition (EndMT) abnormalities seem to be main pathogenic factor in fibroelastosis development. The "gold standard" for diagnosis of primary EFE (pEFE) is the histological examination. Additionally, genetic studies may help to establish the natural course of the disease and to communicate prophylactic measures to family members of the affected child. Moreover, in the newborn, EFE takes the form of dilated cardiomyopathy (DCM) with unfavorable evolution. The proper management should be established considering negative prognostic factors, involving early transplantation, drug therapy and long-term follow-up.

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“…In our embryonic crocodiles, alligators and caimans the cartilage elements have not fused, which was also the case in one juvenile crocodile of approximately 60 cm overall length. Other reptiles [52], terrapin ( [53,54], and turtle [19] present with cartilage prongs.…”

Section: Outflow Tract Separationmentioning

confidence: 99%

Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas With Bicuspid Semilunar Valves

Poelmann¹,

Groot²,

Goerdajal³

et al. 2021

Preprint

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The outflow tract of crocodilians resembles that of birds and mammals as ventricular septation is complete. The arterial anatomy however, presents with a pulmonary trunk originating from the right ventricular cavum, and two aortae originating from either the right or left ventricular cavum. Mixing of blood in crocodilians cannot occur at ventricular level as in other reptiles, but instead takes place at aortic root level by a shunt, the Foramen of Panizza, the opening of which is guarded by two facing semilunar leaflets of both bicuspid aortic valves. Methods. Developmental stages of Alligator mississipiensis, Crocodilus niloticus and Caiman latirostris, have been studied. Results and Conclusions. The outflow tract septation complex can be divided into 2 components. The aorto-pulmonary septum divides the pulmonary trunk from both aortae, whereas the interaortic septum divides the systemic from the visceral aorta. Neural crest cells are most likely involved in the formation of both components. Remodeling of the endocardial cushions and both septa results in the formation of bicuspid valves in all three arterial trunks. The foramen of Panizza originates intracardially as a channel in the septal endocardial cushion.

show abstract

Histology and Immunohistochemistry of the Cardiac Ventricular Structure in the Green Turtle(Chelonia mydas)

Cited by 7 publications

References 32 publications

Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves

Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves

Endocardial fibroelastosis and dilated cardiomyopathy – the past and future of the interface between histology and genetics

Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas With Bicuspid Semilunar Valves

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