Histological variations in liver of freshwater fish Oreochromis mossambicus exposed to 60Co gamma irradiation

Bukhari, Ali; Mohamed, H.E. Syed; Broos, Kees; Stalin, A.; Singhal, R. K.; Venu-Babu, P.

doi:10.1016/j.jenvrad.2012.04.011

Cited by 15 publications

(4 citation statements)

References 29 publications

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“…Lesnik and Jurcina (1994) reported that high doses may cause damage to the gastrointestinal tract, leading to a defect in the intestinal mucosa. Severe histological changes due to radiations were induced in aquatic organisms (Egami et al, 1984;Sadiq Bukhari et al, 2012;Stalin et al, 2013aStalin et al, , 2013b, which is in agreement to our results.…”

Section: Discussionsupporting

confidence: 93%

Effect of gamma radiation on the growth, survival, hematology and histological parameters of rainbow trout (Oncorhynchus mykiss) larvae

et al. 2015

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Section: Discussionsupporting

confidence: 93%

Effect of gamma radiation on the growth, survival, hematology and histological parameters of rainbow trout (Oncorhynchus mykiss) larvae

et al. 2015

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“…We agree with Xing et al [8] and Deb and Das [61], who state that degeneration, pyknotic nuclei, fatty infiltration or total necrosis at different levels of expression, as a result of pesticide intoxication, could be established in the liver parenchyma. According to Bukhari et al [62], the hepatic lesions are associated with the increased toxicant concentrations, which we confirmed in our study. In addition, the production of free radicals, lipid peroxidation and changes in the antioxidant state are vital factors for the toxic effects of pesticides on the liver histological structure [63].…”

Section: Discussionsupporting

confidence: 91%

Multi-Biomarker Assessment in Common Carp (Cyprinus carpio, Linnaeus 1758) Liver after Acute Chlorpyrifos Exposure

Stoyanova

Georgieva

Velcheva

et al. 2020

Water

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The excessive use of pesticides at different stages of crop production can pose a great danger to the aquatic environment, and particularly to fish. The purpose of the present work was to assess the negative effects of chlorpyrifos (CPF) on the liver histological architecture and the activities of marker enzymes in common carp (Cyprinus carpio Linnaeus, 1758), by applying a multi-biomarker technique. The tested insecticide is categorized as a priority pollutant in surface waters in terms of Directive 2013/39/EU. The carps were exposed to different and environmentally relevant CPF concentrations for 72 h (a short-term acute experiment). The results showed that the tested insecticide alters the liver histological structure, causing degenerative lesions, such as granular and vacuolar degeneration; necrobiotic alterations and necrosis, as well as changes in the circulatory system. In addition, CPF induces changes in the enzymatic activity of lactate dehydrogenase (LDH), aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), cholinesterase (ChE), glutathione peroxidase (GPx) and catalase (CAT). The results from such experimental set ups could be successfully used in the legislation related to the protection of water bodies from contamination, in areas with intensive application of plant protection products used in agricultural practices, and also in implementing the Water Frame Directive by using multi-biomarker approaches.

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“…The histopathological changes that occur in the liver are due to increasing concentrations of toxic substances received in the organ (Bukhari et al, 2012), such changes depend not only on the time of exposure of organisms to toxic agents but also on the type of agent and its concentration. Several substances can generate these changes, making them useful as possible non-specific biomarkers in ecotoxicological studies (Yancheva et at., 2016).…”

Section: Sublethal Toxicity Testmentioning

confidence: 99%

Evaluation of the acute and sublethal toxicity of Mancozeb in Pacamã (Lophiosilurus alexandri)

Silva,

Albinati,

Souza

et al. 2023

Braz. J. Biol.

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The toxic potential of dithiocarbamates fungicides widely used in world agriculture is well known, among which Mancozeb is one of the most used. This study aimed to evaluate the toxicity of Mancozeb, determining the LC50% of the product and the behavioral and histological changes observed in fish of the Pacamã species through acute and sublethal toxicity tests. The first experiment was carried out on Pacamã fingerlings exposed to dosages of 0.5, 1, 2, 4, and 8mg/L of Mancozeb under the form ManzateWG®, for a total period of 96 hours in the acute experiment, and in the second experiment, fish were subjected to concentrations of 1/10 of those used in the acute experiment (0.05, 0.1, 0.2, 0.4 and 0.8mg/L, respectively), for 15 days in total. The 50% lethal concentration of ManzateWG® was calculated at the end of the acute experiment, presenting a value of 2.29mg/L at 96h for Pacamã fingerlings. A behavioral assessment was carried out through daily observation of the fish during both experiments, and an increase in mucus production was observed, as well as atypical social behavior in those exposed to the toxic agent. Histopathological evaluation was performed on livers collected after the end of the sublethal experiment, and the main hepatic alterations observed were cytoplasmic vacuolization, inflammatory infiltrate, and necrosis. Mancozeb has toxic potential and is capable of generating behavioral changes, as well as increasing the risk of liver damage in Pacamãs exposed to this compound.

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Histological variations in liver of freshwater fish Oreochromis mossambicus exposed to 60Co gamma irradiation

Cited by 15 publications

References 29 publications

Effect of gamma radiation on the growth, survival, hematology and histological parameters of rainbow trout (Oncorhynchus mykiss) larvae

Effect of gamma radiation on the growth, survival, hematology and histological parameters of rainbow trout (Oncorhynchus mykiss) larvae

Multi-Biomarker Assessment in Common Carp (Cyprinus carpio, Linnaeus 1758) Liver after Acute Chlorpyrifos Exposure

Evaluation of the acute and sublethal toxicity of Mancozeb in Pacamã (Lophiosilurus alexandri)

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