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Cited by 30 publications
(19 citation statements)
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“…Furthermore, the existence of PMNs and parakeratosis is also consistent with underlying epidermal hyperplasia, which shows a high mitotic rate (65). Coexistence of PMNs and parakeratosis is in part explained by the tissue-destructive properties of active oxygen intermediates and proteolytic enzymes that are released by activated PMNs attached to the stratum corneum (81,82) that are opsonized by iC3b through the alternative complement activation (83).…”
Section: A Neutrophil-associated Inflammation-boosting Loop Inducing mentioning
confidence: 71%
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“…Furthermore, the existence of PMNs and parakeratosis is also consistent with underlying epidermal hyperplasia, which shows a high mitotic rate (65). Coexistence of PMNs and parakeratosis is in part explained by the tissue-destructive properties of active oxygen intermediates and proteolytic enzymes that are released by activated PMNs attached to the stratum corneum (81,82) that are opsonized by iC3b through the alternative complement activation (83).…”
Section: A Neutrophil-associated Inflammation-boosting Loop Inducing mentioning
confidence: 71%
“…Interestingly, higher rates of mitotic cells were found at areas of parakeratosis than at those of orthokeratosis, suggesting increased epidermal growth in areas containing PMNs (65). In addition, it is known that pronounced parakeratosis is associated with the presence of PMNs and that microabscesses of Munro are located exclusively within areas of parakeratosis (66).…”
Section: Clinical and Histological Heterogeneity Of Psoriasismentioning
confidence: 99%
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“…In con trast to the histological changes found in the mature psoriatic plaque, the pin-point papules show only slight epidermal proliferation, whereas the changes in the corium, consisting of inflamma tory infiltrates, are more pronounced [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. The sequence of events however remains controversial.…”
Section: Introductionmentioning
confidence: 99%
“…Areas of parakeratosis appear to contain abundant neutrophils (Cox and Watson 1972). In addition, it is known that pronounced parakeratosis is associated with the presence of neutrophils and that Munro's microabscesses are located exclusively within areas of parakeratosis (van de Kerkhof and Lammers 1987).…”
Section: Psoriasis Vulgaris Histological Featuresmentioning
confidence: 99%