Histological, ultrastructural and immunohistochemical studies on the protective effect of ginger extract against cisplatin-induced nephrotoxicity in male rats

Abstract

Cisplatin (CP) is a widely used anticancer drug; however, it has several side effects such as nephrotoxicity. Ginger, the rhizome of Zingiber officinale, consumed since ancient times has numerous health benefits. The objective of this work was to evaluate the protective effect of ginger extract (GE) against CP-induced nephrotoxicity. CP group displayed a marked renal failure characterized by a significant increase in serum creatinine and blood urea nitrogen (BUN) levels in addition to severe histopathological and ultrastructural renal alterations. Also, CP group showed an increase in the immunohistochemical expression of Bax proapoptotic protein. In contrast, GE+CP group showed significant decrease in the elevated serum creatinine and BUN levels and an improvement in the histopathological and ultrastructural renal injury induced by CP. The overexpression of Bax proapoptotic protein was significantly decreased in the GE+CP group. Hence, the present results indicated that GE has a protective effect against CP-induced renal damage in rats. Thereby, such findings recommended the usage of GE to prevent and/or decrease the renal damage induced by CP chemotherapeutic treatment.

The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial

“…In previous studies, there are scavenging effects of zingerone from ginger against intracellular RS (reactive species). Ginger also contains [6]-gingerol, 8-gingerol, 10-gingerol and 12-gingerol, which have similar anti-oxidate properties (27, 31). Animal modeling showed that ginger significantly lowered induced lipid peroxidation and amplified the levels of antioxidant enzymes, quantity and quality of sperm and plus serum glutathione (9, 16, 17, 32).…”

Antioxidant Effect of Silymarin on Cisplatin-Induced Renal Oxidative Stress in Rats

“…In other words, the unbalanced accumulation of CDDP in kidney tissue may result in nephrotoxicity (Arany and Safirstein, 2003) and may cause acute renal failure even after a single dose (Lau, 1999;Sultana et al, 2012). Several researches have been conducted to explain how CDDP could stimulate toxicity (Saad et al, 2009;Ali et al, 2013;Benedetti et al, 2013). However, one of the main mechanisms of CDDP nephrotoxicity is the oxidative stress (Mansour et al, 2002;Sueishi et al, 2002;Uehara et al, 2011).…”

“…The name "milk thistle" is derived from the milky white sap that comes from the leaves and stems when crushed or broken. The SIL has high significance in herbal medicine for its activity in the treatment and protection against variety of diseases including nephrotoxicity (Ali and Moundhri, 2006;Ali et al, 2013). The SIL deleterious effects like gastrointestinal disturbances and allergic skin rashes have been published (El-Shitany et al, 2008).…”

Gingerol Fraction from Zingiber officinale Protects against Gentamicin-Induced Nephrotoxicity

“…Ginger has been shown to protect against renal ischemia-reperfusion injury and cisplatin-related nephrotoxicity (20,21). In the former case, its use has been associated with an antiapoptotic effect.…”