Histological Features, p53, c-Kit, and Poliomavirus Status and Impact on Survival in Merkel Cell Carcinoma Patients

Husein‐ElAhmed, Husein; Ramos-Pleguezuelos, Francisco Manuel; Ruiz-Molina, Inmaculada; Cívico-Amat, Vicente; Solís-García, Eduardo; Galán‐Gutiérrez, Manuel; Ruiz‐Villaverde, Ricardo

doi:10.1097/dad.0000000000000573

Cited by 15 publications

(7 citation statements)

References 29 publications

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“…From a clinical standpoint, male gender, tumor location on the head and neck, large tumor diameter, immunosuppression, and lymph node involvement correlate with a worse prognosis for MCC. 17 From a histopathologic standpoint, lymphovascular invasion (detected on routine sections or with D2‐40 staining), positive staining for p63, and higher mast cell counts are poor prognostic indicators for MCC, while infiltration of the tumor by CD8+ lymphocytes has been found to indicate favorable prognosis . The detection of polyomavirus has been found to be a marker of favorable prognosis in some studies, but other studies have not found this association …”

Section: Discussionmentioning

confidence: 99%

Large‐cell variant of Merkel cell carcinoma with clear‐cell change

Khanna

North

2019

J Cutan Pathol

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Section: Discussionmentioning

confidence: 99%

Large‐cell variant of Merkel cell carcinoma with clear‐cell change

Khanna

North

2019

J Cutan Pathol

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“…47,48 Parameters such as lymphovascular invasion, p53 and p63 immunopositivity, increased mast cell concentration, and vascular density as determined by CD34 staining have been implicated as factors that negatively affect MCC survival. [49][50][51][52][53][54] Lymphovascular invasion can be detected by immunostaining with D2-40 or CD31. 55 Prior MCC literature has demonstrated the prognostic potential of tumor-infiltrating lymphocytes (TIL).…”

Section: Diagnosis Staging and Prognostic Markersmentioning

confidence: 99%

Merkel cell carcinoma: An updated review of pathogenesis, diagnosis, and treatment options

Hernandez

Mohsin

Yaghi

et al. 2022

Dermatologic Therapy

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Merkel cell carcinoma is a rare neuroendocrine carcinoma that typically appears in sun-exposed areas of the elderly. It has a poor prognosis and with its incidence projected to increase, it is vital for dermatologists to remain up to date with recent updates in this malignancy's pathogenesis and treatment. In the past few decades Merkel cell carcinoma's pathogenesis, more specifically its relation to the Merkel cell polyomavirus, has sparked further interest in the study of this carcinoma. Most cases are attributed to malignant transformation secondary to the Merkel cell polyomavirus, with a minority derived from DNA damage resulting from ultraviolet radiation.Investigators have also determined that there are immunologic influences in the development and prognosis of Merkel cell carcinoma, as individuals with HIV, solid organ transplants, and lymphoproliferative malignancies are at a greater risk of developing this carcinoma. In addition, this immunologic link carries treatment value, as immunologic therapies are currently being investigated. This article provides a comprehensive review of the epidemiology and pathogenesis of Merkel cell carcinoma as well as the current treatments available and clinical trials underway. We also touch upon the updated National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology in respect to its diagnosis and recommended treatment modalities.

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“…Weitere prognostische Marker mit negativem Effekt auf das Überleben stellen Tumorgröße, eine p53- und p63-Immunpositivität, eine lymphovaskuläre Infiltration, eine erhöhte Mastzellkonzentration und eine Erhöhung des Endothelzellmarkers CD34 in der Immunhistochemie dar 30 , 31 , 32 , 33 .…”

Section: Staging Und Prognostische Markerunclassified

Das periokuläre Merkel-Zell-Karzinom – eine Übersicht klinischer Aspekte und aktueller Therapieoptionen

Esser

Grünewald

Mihailovic

2022

Klin Monbl Augenheilkd

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ZusammenfassungDas Merkel-Zell-Karzinom (MCC) stellt einen seltenen, jedoch hochaggressiven und rasch expandierenden malignen Hauttumor dar. Die periokuläre Region ist in etwa 10% der Fälle betroffen. Die aktuelle Therapieempfehlung des resektablen, nicht metastasierten MCC umfasst die chirurgische Totalexzision, allerdings sind bei Diagnosestellung bereits häufig Lymphknoten- oder Fernmetastasen vorhanden. Seit der Erstzulassung einer Immun-Checkpoint-Inhibitor-Therapie mit Avelumab für das metastasierte MCC im Jahr 2016 hat sich das mittlere Überleben im Vergleich zur zytostatischen Therapie erheblich gebessert bei gleichzeitig seltenerem Auftreten schwerwiegender therapieassoziierter unerwünschter Ereignisse. Weitere Immun-Checkpoint-Inhibitoren mit ersten vielversprechenden Ergebnissen sind derzeit noch in der klinischen Erprobung. Eine interdisziplinäre Betreuung an einem spezialisierten Zentrum mit Vorstellung in einem Tumorboard ist bei Patienten MCC aufgrund der komplexen Diagnostik, Therapie und Prognoseabschätzung essenziell.

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Histological Features, p53, c-Kit, and Poliomavirus Status and Impact on Survival in Merkel Cell Carcinoma Patients

Cited by 15 publications

References 29 publications

Large‐cell variant of Merkel cell carcinoma with clear‐cell change

Large‐cell variant of Merkel cell carcinoma with clear‐cell change

Merkel cell carcinoma: An updated review of pathogenesis, diagnosis, and treatment options

Das periokuläre Merkel-Zell-Karzinom – eine Übersicht klinischer Aspekte und aktueller Therapieoptionen

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