Histological evaluation of two different anorganic bovine bone matrixes in lateral wall sinus elevation procedure: A retrospective study

Abstract

Introduction: Grafting in oral implantology involves bone augmentation procedures with various bone graft materials. Success of such procedures is evaluated through the amount of bone volume and bone formed at the grafted site. The primary aim of this prospective study was to histomorphometrically evaluate and compare the new bone formation with Bio Oss or Cerabone in the lateral approach sinus augmentation procedure. Materials and Methods: The research targeted 22 patients who were either partially or completely edentulous posterior maxilla with residual alveolar height 3 mm at the site of implantation and underwent a two staged surgical protocol, with a lateral approach sinus grafting with either Bio Oss or Cerabone. Bone trephine biopsies for histological analysis were harvested 6 months after augmentation while preparing the osteotomies for implant placement trephine. The histologic evaluation was performed comparing the newly formed bone, marrow spaces, biomaterial particles remnants, and presence of osteocytes embedded in both trabecular bone and bone tissue near the anorganic bovine bone. Results: The present study showed that neither of the graft material showed any active osteoclasts and host inflammatory reaction. From sites grafted with Cerabone, an ample amount of mature lamellated bone formation was seen, also host inflammatory response was indicative of minimal reactive inflammatory response suggestive of good acceptability of the graft material by the host. No significant differences between the groups could be detected with regard to new bone formation and residual bone substitute. Conclusion: The results of the study illustrates that both the bone substitute materials allow predictable new bone formation in sinus augmentation procedures.

Assessment of the Bone Healing Process Mediated by Periosteum-Derived Mesenchymal Stem Cells’ Secretome and a Xenogenic Bioceramic—An In Vivo Study in the Rabbit Critical Size Calvarial Defect Model

“…Cerabone ® is a particulate bioceramic xenograft, prepared from bovine femoral heads, submitted to complex physical-chemical purification methods, including the thermal treatment with temperatures up to 1250 • C [50,51]. It has a validated biocompatibility and has been applied with success in distinct settings, sustaining an enhancement of the bone healing and regeneration processes, in both experimental and clinical applications [52][53][54].…”

A comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review

“…The study enrolled 22 patients with approximately 3 mm residual bone height who underwent two-stage implant placements. Histological analysis after 6 months revealed no differences between new bone formation and residual BS material [ 40 ]. In a RCT, a comparison was made between a high-temperature treated particulate bovine BS (Alpha Bio’s Graft®, a private label of cerabone®, botiss biomaterials GmbH, Zossen, Germany) and a low-temperature treated one (Bio-Oss®) for sinus floor elevation.…”

“…Deproteinized bovine BS comprises an inorganic hydroxyapatite-supported structure with osteoconductive properties and protracted resorption kinetics [ 36 – 38 ]. Residual graft material has been detected even a decade post-augmentation, but the extent of osteoclastic activity surrounding bovine BS remains debatable [ 16 , 39 , 40 ]. Given the variety of particulate bovine BS available, it remains to be seen which BS is most suitable for specific clinical scenarios, each with its advantages and limitations.…”

Recent Advances in Bone Grafts in Oral and Maxillofacial Surgery

“…[9,19].Human DBM in the form of putty has been successfully used to preserve and restore alveolar bone height and thickness after tooth extraction. This leads to the formation of mineralized and mature bone within six months after grafting [20,21].…”