Histological evaluation of alveolar ridge augmentation using injectable calcium phosphate bone cement in dogs

Abstract

Alveolar ridge augmentation is an important procedure to restore tooth loss. Several types of graft materials have been used for augmenting the alveolar ridge. An injectable calcium phosphate cement (CPC) has been applied to periodontal bone defects and has shown favourable results. Thus, this CPC may work as an effective graft material for alveolar ridge augmentation. The aim of this study was to evaluate the effectiveness of the CPC for large-scaled (about 7 x 8 x 6 mm) ridge augmentation in dogs. Alveolar ridge defects were created bilaterally in the maxilla of six beagle dogs. The CPC was applied to one of the bilateral maxillary defects. The untreated defect on the contralateral side served as control. The animals were sacrificed at 6 months after surgery and decalcified histological specimens of the alveolar ridge were prepared histometrically and evaluated under a light microscope. Newly formed and reconstructed alveolar ridges covering the CPC were observed in all experimental sites. In the control sites, only slight newly bone formation was observed. Histomorphometrical analysis indicated that the CPC grafted group exhibited significantly (P = 0.0001) increased area and height in new bone formation compared with those of the control group. The results indicate that the CPC appears to be an effective material for alveolar ridge augmentation and may act as a space maintainer to conduct new bone formation.

Ridge augmentation using recombinant human fibroblast growth factor‐2 with biodegradable gelatin sponges incorporating β‐tricalcium phosphate: a preclinical study in dogs

“…In this study, because of the limitations of the surgical sites, we were unable to create a sham operation site as a control. However, when compared with a previous study , albeit with some differences in defect size (8 mm high and 7 mm wide), the height of new bone formed at sham operation sites (0.6 ± 0.3 mm) was much less than at our control sites.…”

“…A). Bilateral saddle‐type bone defects (5 mm high and 10 mm wide) were surgically created 3 mm mesial to the canine, according to a previous report with slight modification (Fig. B).…”

Histologic changes in the sinus membrane after maxillary sinus augmentation with simultaneous implant placement using engineered bone graft material

“…CPC is proved to be an ideal bone substitute with biocompatible, osteoconductive and osteoinductive, and easy to be fabricated into functional shapes and controlled biological absorption ability, resorbable in a manner of creeping substitution [13] . The use of porous CPC alone as grafting material has been reported on alveolar ridge augmentation, maxillofacial reconstruction and cranial defect reparation [14] . Autogenous BMSCs do not appear to be rejected by the immune system and have obvious ability of bone formation [15] .…”

Calcium Orthophosphates (CaPo ) and Dentistry

“…However, as written in section 2, the vast majority of the publications on this subject deals with a treatment of the surrounding bones and, thus, they fall into a category of bone substitutes, which is another story. Nevertheless, the following directions of CaPO 4 application in oral and maxillofacial surgery can be outlined: coatings on various types of dental implants [330][331][332][333][334][335][336][337][338][339][340][341][342][343][344][345]403,[519][520][521][522][523][524] Orthodontics: According to the databases, the earliest publications on use of CaPO 4 in orthodontics appeared in 1989 [409][410][411]. Coatings of CaPO 4 (both HA [413] and α-TCP [295]) were successfully applied to titanium implants and the coated implants were found to be applicable as anchorage for short-term orthodontic treatment [413] and both types of coatings appeared to be effective stimulators of new bone formation [295].…”