Histological assessment of porous custom-made hydroxyapatite implants 6 months and 2.5 years after cranioplasty

Ono, Hajime; Sase, Taigen; Tanaka, Yuichiro; Takasuna, Hiroshi

doi:10.4103/2152-7806.198735

Cited by 20 publications

(20 citation statements)

References 26 publications

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“…Hydroxyapatite-based biomaterials possess osteoconductive properties and can also act as three-dimensional scaffolds to support bone regeneration [1]. However, introducing biomaterials into the body can lead to metabolic alterations.…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Vitamins K and D3 on Redox Balance of Human Osteoblasts Cultured with Hydroxyapatite-Based Biomaterials

Ambrożewicz

Muszyńska

Tokajuk

et al. 2019

Cells

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Hydroxyapatite-based biomaterials are commonly used in surgery to repair bone damage. However, the introduction of biomaterials into the body can cause metabolic alterations, including redox imbalance. Because vitamins D3 and K (K1, MK-4, MK-7) have pronounced osteoinductive, anti-inflammatory, and antioxidant properties, it is suggested that they may reduce the adverse effects of biomaterials. The aim of this study was to investigate the effects of vitamins D3 and K, used alone and in combination, on the redox metabolism of human osteoblasts (hFOB 1.19 cell line) cultured in the presence of hydroxyapatite-based biomaterials (Maxgraft, Cerabone, Apatos, and Gen-Os). Culturing of the osteoblasts in the presence of hydroxyapatite-based biomaterials resulted in oxidative stress manifested by increased production of reactive oxygen species and decrease of glutathione level and glutathione peroxidase activity. Such redox imbalance leads to lipid peroxidation manifested by an increase of 4-hydroxynonenal level, which is known to influence the growth of bone cells. Vitamins D3 and K were shown to help maintain redox balance and prevent lipid peroxidation in osteoblasts cultured with hydroxyapatite-based biomaterials. The strongest effect was observed for the combination of vitamin D3 and MK-7. Moreover, vitamins promoted growth of the osteoblasts, manifested by increased DNA biosynthesis. Therefore, it is suggested that the use of vitamins D3 and K may protect redox balance and support the growth of osteoblasts affected by hydroxyapatite-based biomaterials.

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Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Vitamins K and D3 on Redox Balance of Human Osteoblasts Cultured with Hydroxyapatite-Based Biomaterials

Ambrożewicz

Muszyńska

Tokajuk

et al. 2019

Cells

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“…In 95% percent of cases, it is accompanied by hydrocephalus and myelomeningocele. Types 3 and 4 are rare [ 1 , 2 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancy itself, uterine contractions and maternal effort during vaginal delivery could increase intracranial pressure, aggravate maternal symptoms and worsen the condition. Anesthesia for labor analgesia or obstetric surgery is a matter of debate as general, epidural or spinal anesthesia can all have consequences [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Arnold-Chiari malformation and significant lumbar disc prolapse in pregnancy: A case report and literature review

Opoku

Mathew

Thode

et al. 2021

Case Reports in Women's Health

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A 30-year-old woman (gravida 3, para 1 + 1), with a previous uncomplicated pregnancy and vaginal delivery, was diagnosed with both type 1 Arnold-Chiari malformation and symptomatic multi-level lumbar disc prolapse in her inter-pregnancy period. During this index pregnancy, she experienced progressively worsening occipital headaches radiating to both arms, severe low back pain radiating to both legs and weakness in both legs. She had no urinary or bowel symptoms. She was successfully managed through pregnancy by a multidisciplinary team that included obstetricians, orthopedic and neurosurgeons, obstetric anesthetists and physiotherapists. She had an uncomplicated cesarean delivery under spinal anesthesia. As far as we can tell, this is the first report of both conditions in a pregnant woman.

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“…In contrast, hydroxyapatite porous ceramic have a chemical composition that stimulates osteoblast colonization and osteointegration in up to 83.3% of cases [5] . Ono et al [6] showed the new bone formation in vivo after cranioplasty. Furthermore, a ceramic implant may be successfully used to cover a large skull defect after bone removal in a single-step reconstructive procedure under image guidance [7] , and the feasibility of cranioplasty using hydroxyapatite ceramic has already been reported in pediatric patients [5,8,9] .…”

Section: Discussionmentioning

confidence: 99%

Use of a 3D Skull Model to Improve Accuracy in Cranioplasty for Autologous Flap Resorption in a 3-Year-Old Child

Maduri

Viaroli²,

Levivier³

et al. 2017

Pediatr Neurosurg

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Cranioplasty is considered a simple reconstructive procedure, usually performed in a single stage. In some clinical conditions, such as in children with multifocal flap osteolysis, it could represent a surgical challenge. In these patients, the partially resorbed autologous flap should be removed and replaced with a precustomed prosthesis which should perfectly match the expected bone defect. We describe the technique used for a navigated cranioplasty in a 3-year-old child with multifocal autologous flap osteolysis. We decided to perform a cranioplasty using a custom-made hydroxyapatite porous ceramic flap. The prosthesis was produced with an epoxy resin 3D skull model of the patient, which included a removable flap corresponding to the planned cranioplasty. Preoperatively, a CT scan of the 3D skull model was performed without the removable flap. The CT scan images of the 3D skull model were merged with the preoperative 3D CT scan of the patient and navigated during the cranioplasty to define with precision the cranioplasty margins. After removal of the autologous resorbed flap, the hydroxyapatite prosthesis matched perfectly with the skull defect. The anatomical result was excellent. Thus, the implementation of cranioplasty with image merge navigation of a 3D skull model may improve cranioplasty accuracy, allowing precise anatomic reconstruction in complex skull defect cases.

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Histological assessment of porous custom-made hydroxyapatite implants 6 months and 2.5 years after cranioplasty

Cited by 20 publications

References 26 publications

Beneficial Effects of Vitamins K and D3 on Redox Balance of Human Osteoblasts Cultured with Hydroxyapatite-Based Biomaterials

Beneficial Effects of Vitamins K and D3 on Redox Balance of Human Osteoblasts Cultured with Hydroxyapatite-Based Biomaterials

Arnold-Chiari malformation and significant lumbar disc prolapse in pregnancy: A case report and literature review

Use of a 3D Skull Model to Improve Accuracy in Cranioplasty for Autologous Flap Resorption in a 3-Year-Old Child

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