Histological and Ultrastructural Analyses of Muscle Damage Induced by a Myotoxin Isolated from Bothrops alternatus Snake Venom

Snake envenomations are responsible for a high percentage of deaths, as these toxic proteins induce severe local and systemic effects. In Brazil, the Bothrops genus is responsible for a satisfactory fraction of accidents, including Bothropsalternatus, recognized as urutu, whose venom is capable of inducing severe myotoxicity. In this work, the BaMtox toxin was purified through a combination of three chromatographic steps, ion exchange in DEAE-Sepharose, affinity in Benzamidine Sepharose 6B columns and reversed-phase HPLC chromatography on a C18 column. The BaMtox toxin has a molecular mass of approximately 14kDa and did not show phospholipase activity or hemorrhage. On the other hand, it induced edema and a significant increase in plasma levels of the creatine kinase enzyme. Thus, the protein called BaMtox is able to induce myotoxicity.

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BaMtox, a Myotoxic Enzyme Isolated from the Venom of the Bothrops Alternatus

Alves

Frare

Achê

et al. 2022

JSM

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Histological and Ultrastructural Analyses of Muscle Damage Induced by a Myotoxin Isolated from Bothrops alternatus Snake Venom

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BaMtox, a Myotoxic Enzyme Isolated from the Venom of the Bothrops Alternatus

BaMtox, a Myotoxic Enzyme Isolated from the Venom of the Bothrops Alternatus

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