Histological alterations in the liver of rats induced by different gold nanoparticle sizes, doses and exposure duration

Abdelhalim, Mohamed Anwar K; Jarrar, Bashir M.

doi:10.1186/1477-3155-10-5

Cited by 103 publications

(58 citation statements)

References 18 publications

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“…This mechanism is well reported for gold nanoparticles and many researchers claim it to be the key molecular event for its pharmacological activity (68). At the same time, gold nanoparticles have shown mutagenicity, genotoxicity and cytotoxicity in a number of studies and the mechanism evaluated for the cause of damage is increased reactive oxygen species (ROS).…”

Section: Special Case: Oxidation Stressmentioning

confidence: 99%

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

et al. 2016

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-Nanotechnology has opened a new horizon of research in various fields including applied physics, chemistry, electronics, optics, robotics, biotechnology and medicine. In the biomedical field, nanomaterials have shown remarkable potential as theranostic agents. Materials which are considered inert are often used in nanomedicine owning to their nontoxic profile. At nanoscale, these inert materials have shown unique properties that differ from bulk and dissolved counterparts. In the case of metals, this unique behavior not only imparts paramount advantages but also confers toxicity due to their unwanted interaction with different cellular processes. In the literature, the toxicity of nanoparticles made from inert materials has been investigated and many of these have revealed toxic potential under specific conditions. The surge to understand underlying mechanism of toxicity has increased and different means have been employed to overcome toxicity problems associated with these agents. In this review, we have focused nanoparticles of three inert metallic materials i.e. gold, silver and iron as these are regarded as biologically inert in the bulk and dissolved form. These materials have gained wider research interest and studies indicating the toxicity of these materials are also emerging. Oxidative stress, physical binding and interference with intracellular signaling are the major role player in nanotoxicity and their predominance is highly dependent upon size, surface coating and administered dose of nanoparticles. Current strategies to overcome toxicity have also been reviewed in the light of recent literature. The authors also suggested that uniform testing standards and well-designed studies are needed to evaluate nanotoxicity of these materials that are otherwise considered as inert.

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Section: Special Case: Oxidation Stressmentioning

confidence: 99%

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

et al. 2016

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“…Histopathologic examination confirmed these injures; bile duct hyperplasia, congestive dilation of the central veins, necrosis, fibrosis, and abnormal pigmentation can often be seen. 295,309 Nanoparticles may also aggravate stress-induced apoptosis in the liver, suggesting that they may be especially dangerous to patients with liver disease. 310 Only a few investigations have studied the effect of nanoparticles on liver functions.…”

Section: Hepatotoxicity Caused By Nanoparticlesmentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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“…Here, we resume current information on negative effects of NPs especially including their toxicity (Figure 1) [5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

Jennifer¹,

Wnuk²

2013

JBNB

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Nanoparticles are considered as powerful tools in nanotechnological applications. Due to their unique physicochemical properties, their interactions with different biological systems have been shown. Nanomaterials have been successfully used as coating materials or treatment and diagnosis tools. Nevertheless, toxic effects of nanoparticles in vitro and in vivo have also been reported. Here, we summarize the current state of knowledge on exposure routes, cellular uptake and toxicological activities of the commonly used nanoparticles. In this context, we discuss the mechanisms of toxicity of nanoparticles involving perturbation of redox milieu homeostasis and cellular signaling pathways.

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Histological alterations in the liver of rats induced by different gold nanoparticle sizes, doses and exposure duration

Cited by 103 publications

References 18 publications

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

Perturbation of physiological systems by nanoparticles

Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

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