Histologic responses of port-wine stains treated by argon, carbon dioxide, and tunable dye lasers. A preliminary report

Tan, Oon Tian

doi:10.1001/archderm.122.9.1016

Cited by 51 publications

(34 citation statements)

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“…High-fluence laser irradiation of microvessels causes ultrastructural perturbation of the endothelial cell membrane and denudation of the endothelial monolayer [13,44,45], which triggers primary [46,47] and secondary hemostasis [42]. It should be noted that the volumetric heat production, m a Áf, where m a is the absorption coefficient (cm À1 ) and f is the fluence rate (J/cm 2 ), that led to such endothelial damage [13] was very high ($17,656 kJ/cm 3 , section-S10.1) and not representative for either the clinical setting or our model.…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that the volumetric heat production, m a Áf, where m a is the absorption coefficient (cm À1 ) and f is the fluence rate (J/cm 2 ), that led to such endothelial damage [13] was very high ($17,656 kJ/cm 3 , section-S10.1) and not representative for either the clinical setting or our model. However, Tan et al [44,45], who employed a substantially shorter pulse duration and much larger spot size for treating PWS, showed that endothelial damage can be achieved at significantly lower m a Áf. Contrastingly, at a thousand-fold lower m a Áf of $16 kJ/cm 3 (section-S10.2), thermal coagulum formation and endothelial denudation were absent and only one component of the hemodynamic response (platelet adhesion and aggregation) prevailed, albeit transiently [18].…”

Section: Discussionmentioning

confidence: 99%

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Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains

Heger

Salles

Bezemer

et al. 2011

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains

Heger

Salles

Bezemer

et al. 2011

Journal of Dermatological Science

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“…Plots of percent blood volume versus depth may be used to quantitatively track the progress of laser PWS treatment. As the enlarged blood vessels are replaced with normal capillaries, the percent volume of blood is expected to decrease at the depths that have been successfully treated [18]. …”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Reconstruction of Blood Vessels from in vivo Color Doppler Optical Coherence Tomography Images

Barton

Izatt

Kulkarni³

et al. 1999

Dermatology

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Purpose: Current laser treatment for vascular disorders such as port wine stains can have incomplete or unacceptable results. A customized treatment strategy based on knowledge of the patient’s blood vessel structure may effect an improved clinical outcome. Procedure: We tested the feasibility of using color Doppler optical coherence tomography (OCT) and image processing techniques to locate, measure and reconstruct cutaneous blood vessels in rat and hamster skin. OCT is a recent, potentially noninvasive technique for imaging subsurface tissue structures with micrometer scale resolution. Results: Blood vessels were identified in a series of cross-sectional images, then a three-dimensional reconstruction was made. Parameters that can affect optimum laser treatment parameters, such as average blood vessel depth and luminal diameter, were found from the images. Conclusion: This study shows that color Doppler OCT is a potential tool for improving laser treatment of vascular disorders.

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“…Hemoglobin has high absorption peaks around 577 nm as well as in the green-blue spectral range [2]. However, it has been shown that damage to healthy skin can be reduced by using yellow lasers instead of blue-green lasers due to reduced absorption by epidermis [3]. In addition to wavelength, the mode of operation of the laser (i.e.…”

Section: Introductionmentioning

confidence: 99%

Pulsed high-power yellow-orange VECSEL

et al. 2014

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We report on the development of a pulsed high-power frequency doubled vertical-external-cavity surface-emitting laser (VECSEL) with a peak output power of 14 W and emission spectrum near 588 nm. The semiconductor gain chip was grown by molecular beam epitaxy and comprised 10 GaInAs quantum wells. The gain structure was designed to be antiresonant at 1180 nm. The fundamental wavelength was frequency doubled to the yellow-orange spectral range using a 10-mm long critically phase matched lithium triborate nonlinear crystal, situated at the mode waist of the V-shaped laser cavity. The emission spectrum was narrowed down to FWHM of < 0.2 nm by employing a 1.5 mm birefringent filter and a 100-µm-thick etalon inside the cavity. By directly modulating the pump laser of the VECSEL, we were able to produce pulse widths down to 570 ns with average and peak output power of 81 mW and 14 W, respectively. The repetition rate was kept constant at 10 kHz throughout the measurements. The maximum peak power obtained was pump power limited. In comparison, at the same coolant temperature, a maximum of 8.5 W was achieved in continuous wave. The maximum optical-to-optical conversion efficiency (absorbed peak pump power to peak output power) was calculated to be 20-21 %.

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Histologic responses of port-wine stains treated by argon, carbon dioxide, and tunable dye lasers. A preliminary report

Cited by 51 publications

References 0 publications

Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains

Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains

Three-Dimensional Reconstruction of Blood Vessels from in vivo Color Doppler Optical Coherence Tomography Images

Pulsed high-power yellow-orange VECSEL

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