Histologic artifacts of benign pigmented nevi

Sagebiel, R. W.

doi:10.1001/archderm.106.5.691

Cited by 8 publications

(1 citation statement)

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“…3 We did not find any site-specific unusual histopathological feature as mentioned by other authors except in 1 case from conjunctiva which showed worrisome atypia. 3,15 Stoma showed secondary changes including artifactual cleft formation in 24 cases as also mentioned by Sagebiel RW et al 16 Association of other secondary lesions with nevus are known. 3 We have seen 1 case each of epithelial inclusion cyst and basal cell carcinoma as also noted by other authors.…”

Section: Discussionmentioning

confidence: 73%

Benign melanocytic lesions with emphasis on melanocytic nevi – A histomorphological analysis

Ghosh¹,

Ghartimagar²,

Thapa³

et al. 2018

J Pathol Nep

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Background: Melanocytic lesions are common and include both benign and malignant conditions. Benign melanocytic nevus may show varied microscopic features and should be differentiated from malignant lesions. In the present study, we analyse the histopathological pictures of different types of benign melanocytic nevi.Materials and methods: This study was a hospital based retrospective study and all the cases reported as melanocytic nevus in the period from Jan 2014 to June 2018 in the Department of Pathology, Manipal Teaching Hospital were retrieved and analysed in the study.Results: A total of 104 melanocytic lesions including 74 cases of benign melanocytic nevus were reported in the study period. Females were affected more with a female to male ratio of 1.8:1. The age range was 5 to 78 years with mean age of 28 years. Among the female patients, the commonest age group was 21-30 years while among the males; the most affected age group was 11-20. The commonest histopathological subtype was intradermal nevus comprising 73% cases followed by compound nevus. On analysis of the different sites involved, face, head and neck were found to comprise 92% cases. Epidermal changes including hyperkeratosis, acanthosis were common in intradermal nevus. In most cases, tumor cells were arranged in nests. Melanin pigment was noted in majority of the cases. Secondary changes noted were chronic inflammation, fibrosis and multinucleated giant cells.Conclusion: Benign melanocytic nevus may present in varied age range and show wide spectrum of histological features. All pigmented lesions should be biopsied for its subtypes.

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Section: Discussionmentioning

confidence: 73%

Benign melanocytic lesions with emphasis on melanocytic nevi – A histomorphological analysis

Ghosh¹,

Ghartimagar²,

Thapa³

et al. 2018

J Pathol Nep

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Acquired Melanocytic Nevus

Plaza

Prieto

2017

Pathology of Pigmented Skin Lesions

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Pseudolipomatosis Cutis: Superficial Dermal Vacuoles Resembling Fatty Infiltration of the Skin

Trotter

Crawford²

1998

The American Journal of Dermatopathology

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Empty spaces within the dermis of paraffin-embedded sections of skin have been attributed to fatty infiltration and postulated to originate from topical steroid administration or sebaceous gland rupture. We examined skin biopsy specimens exhibiting dermal vacuolation to determine whether this phenomenon was associated with specific skin diseases and to attempt to illuminate its etiology. Routine hematoxylin-eosin-stained sections from 26 formalin-fixed, paraffin-embedded biopsy specimens were examined. Histochemical stains for mucin and immunohistochemical staining for S100 protein and vascular markers were performed. Dermal vacuolation was characterized by empty spaces, 15-120 microm in diameter, in the superficial dermis, associated with either fibrosis/sclerosis or a lymphocytic infiltrate. There was no relationship to clinical findings, topical steroid treatment, or histologic diagnosis. There was no evidence of true adipocyte differentiation, and vascular markers were negative. Transmission electron microscopy showed nonmembrane-bound irregular spaces in the dermis. Dermal vacuoles likely represent an artifact of tissue fixation or processing and are unrelated to the underlying pathologic process. We propose the name pseudolipomatosis cutis, analogous to insufflation-induced colonic vacuolation, to distinguish this phenomenon from true dermal fatty infiltration and to emphasize its incidental, likely artifactual nature.

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Histologic artifacts of benign pigmented nevi

Cited by 8 publications

References 0 publications

Benign melanocytic lesions with emphasis on melanocytic nevi – A histomorphological analysis

Benign melanocytic lesions with emphasis on melanocytic nevi – A histomorphological analysis

Acquired Melanocytic Nevus

Pseudolipomatosis Cutis: Superficial Dermal Vacuoles Resembling Fatty Infiltration of the Skin

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