Histogenesis of skin appendage tumors

Hidroacanthoma simplex: an ultrastructural study

“…Cystic spaces and lumen formation may be identified in all three tumor types (Smith & Coburn 1956, Bardach 1978 and the tumor cells contain considerable quantities of glycogen. Similar enzyme histochemical profiles have been found in eccrine poroma (Hashimoto & Lever 1969;Sanderson & Ryan 1963), hidroacanthoma simplex (Holubar & Wolff 1969), and the eccrine duct (Dobson & Montagna 1974). The acrosyringium (Pinkus 1939) or intraepithelial portion of the eccrine sweat duct is dis-tinct from the surrounding epidermis and is derived from luminal cells of the superficial dermal eccrine duct which migrate into the epidermis (Lobitz et al 1954, Christophers & Plewig 1973.…”

Solitary giant vulval syringoma

“…S ir , The syringoma is a benign dermal tumour, usually found in groups of multiple small lesions. Although most commonly seen on the face, neck and chest, there have been infrequent reports of lesions on the genitals of both females and males 1 –9 . We describe a single giant syringoma of the vulva, which has not, to our knowledge, been reported previously.…”

Immunohistochemical expression of bone morphogenetic protein-2 in pilomatricoma

“…Shadow cells show strong birefringence in polarized light, similar to the keratogenous zone of hair. 2 Given the agreement between histological, histochemical and ultrastructural findings, basophilic cells correspond to hair matrix cells, and shadow cells correspond to hair cortex cells. Depending on its stage of differentiation, pilomatricoma is classified into three phases: a progressive phase, a regressive phase, and the phase of dismantling and reconstruction by stroma.…”