Histocompatibility antigens in psoriasis, psoriatic arthropathy, and ankylosing spondylitis.

Armstrong, Ray; Panayi, G. S.; Welsh, K

doi:10.1136/ard.42.2.142

Cited by 84 publications

(36 citation statements)

References 15 publications

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“…6 In marked contrast, in psoriasis, HLA-B*27 has only occasionally been reported as significantly but slightly increased. 25,26 The increased frequency of HLA-B*39 in PsA was also detected serologically. 17 Three haplotypes containing B*27 or B*39:01 were significantly increased in frequency in the PsA cohort, 15.6% versus 5.5% in reference controls, but were not increased in the psoriasis cohort (4.7%).…”

Section: Hla Alleles and Psa Susceptibilitymentioning

confidence: 93%

Epidemiology, genetics and management of psoriatic arthritis 2013: focus on developments of who develops the disease, its clinical features, and emerging treatment options

Haroon¹,

FitzGerald²,

Winchester

2013

PTT

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Abstract:The picture of elements comprising the genetic susceptibility to develop psoriatic arthritis, especially those involving human leukocyte antigen alleles, is emerging in much greater clarity because of improvements in the methods of psoriatic arthritis ascertainment and in the technology of genetic typing. This new knowledge suggests there is genetic heterogeneity in the psoriasis phenotype, and that there are several genetically and clinically different forms of psoriatic arthritis. These genetic studies on psoriatic arthritis further reinforce the relationship of psoriatic arthritis to the other spondyloarthritides, but also raise novel questions of whether the effect of certain susceptibility genes may differ among them. Considerable evidence indicates that the clinical features reflect a CD8 T lymphocyte-driven immune response is present that is characterized by clonal expansion and differentiation towards memory-effector phenotypes. With the aid of new classification criteria, the typical clinical features of psoriatic arthritis involving different joints, entheses, and their related compartments are being better defined as distinctive characteristics of psoriatic arthritis or of the spondyloarthritis group of disorders. In the evaluation of an individual with psoriatic arthritis, taking a patient-focused perspective is recommended, which has the potential to enhance their quality of life significantly. The choice of current and emerging therapeutic agents from an increasing realm of conventional and biologic agents is becoming much better rationalized and more firmly based on evidence from clinical trials.

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Section: Hla Alleles and Psa Susceptibilitymentioning

confidence: 93%

Epidemiology, genetics and management of psoriatic arthritis 2013: focus on developments of who develops the disease, its clinical features, and emerging treatment options

Haroon¹,

FitzGerald²,

Winchester

2013

PTT

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“…These associations are with HLA B17 (1-10) B13 (1 -9. 11), Cw6 (6-12) and DR7 (6)(7)(8)(9)(10)(11). Both HLA B13 and BI7 are in link age disequilibrium with Cw6.…”

Section: Discussionmentioning

confidence: 99%

Complement Phenotypes in Patients with Psoriasis<sup>1</sup>

Wang²,

Ec³

et al. 1989

Hum Hered

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Phenotype frequencies for the complement proteins C4A, C4B, Bf (factor B) and C3 were performed for 49 Caucasian patients with psoriasis. The C4*A6 allele was present in 26.6% of the patients as compared to 5.4% of healthy regional Caucasian controls, p < 0.001, relative risk = 6.28. The C4*A6 allele is known to be in linkage disequilibrium with the HLA B17 allele and to produce a non-functional gene product when it occurs with the B17 allele. HLA B17 is known to be associated with psoriasis in many Caucasian populations. Additional findings in the present study were a significant reduction in the C4B*2 allele frequency, a non-significant increase in the Bf*F allele frequency and no difference for Bf or C3 phenotype frequencies in the patients with psoriasis as compared to the controls.

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“…Furthermore some associations, or the statistical significance of them, which have been found in some populations were not confirmed in studies performed on different ethnic groups. On this regard we focus on the association of B13, B17/Cw6 and DR7 with the oligoarticular asymmetric subset (11,(13)(14)(15), as well as B16 and his splits B38 and B39. Similarly, DR4 has been associated with the peripheral symmetric polyarticular subset (9,10,12,13,17) while B27 has been classically linked with the axial sacroiliitis involvement (15,18), expecially in bilateral sacroiliitis (19), with the exception of the population in Israel where this association has not been observed (20).…”

mentioning

confidence: 99%

“…Although clear differences have been found among the populations studied, both HLA class I and II alleles have been associated with PsA. Among the first ones, HLA-B13, B17/Cw6, B16 with his splits B38 and B39 (the last one is also associated with disease progression) and B27 are included; among class II alleles, DR7 and DR4 are implicated (9)(10)(11)(12)(13)(14)(15)(16)(17). The presence of two susceptibility alleles, have been shown to confer an additional risk; this has been demonstrated for Cw1 and B17 when associated with B27 in the spondylitic subset (15).…”

mentioning

confidence: 99%