Histiocytoid Sweet Syndrome

Requena, Luis; Kutzner, Heinz; Palmedo, Gabriele; Pascual, Marta; Fernández‐Herrera, Jesús; Fraga, Javier; García‐Diez, Amaro; Yus, Evaristo Sánchez

doi:10.1001/archderm.141.7.834

Cited by 206 publications

(64 citation statements)

References 20 publications

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“…A report of 41 cases of Sweet syndrome showed that the dermal infiltrate was composed of monocytic-histiocyticeappearing cells which were strongly positive with myeloperoxidase, characterizing the nature of the inflammatory infiltrate as granulocytic in origin. 4 For Sweet syndrome with the histologic and immunohistochemical findings of monocytic-histiocytic infiltrate over the classic neutrophilic infiltrate, the authors proposed the name ''histiocytoid Sweet syndrome.'' 4 In a recent series of 9 patients with recurrent Sweet syndrome, the initial dermal infiltrate was composed of lymphocytes and atypical mononuclear cells.…”

Section: Discussionmentioning

confidence: 99%

“…4 For Sweet syndrome with the histologic and immunohistochemical findings of monocytic-histiocytic infiltrate over the classic neutrophilic infiltrate, the authors proposed the name ''histiocytoid Sweet syndrome.'' 4 In a recent series of 9 patients with recurrent Sweet syndrome, the initial dermal infiltrate was composed of lymphocytes and atypical mononuclear cells. In all 9 patients there was an associated myelodysplastic syndrome.…”

Section: Discussionmentioning

confidence: 99%

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Bortezomib-induced histiocytoid Sweet syndrome

Murase

Théate

et al. 2009

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bortezomib-induced histiocytoid Sweet syndrome

Murase

Théate

et al. 2009

Journal of the American Academy of Dermatology

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“…4,21 In the cases reported by Requena et al, these cells showed strong reactivity to the anti-myeloperoxidase antibody, suggesting that they are immature myeloid cells, precursors of neutrophils, which are found in early lesions. 4 In these cases, myeloid leukemia was not confirmed, despite the immature appearance of the cells composing the cellular infiltrate in the dermis and hypodermis. The same occurred in the majority of the cases evaluated by Chow et al, in which, however, there was a case of leukemia cutis that was later confirmed.…”

mentioning

confidence: 91%

“…Contradictory findings with respect to the composition of the inflammatory infiltrate, its location and the presentation of a histiocytoid Sweetís syndrome have attracted the interest of investigators, justifying the evaluation of a larger number of cases. 3,4 The objective of the present study was to evaluate the demographic, clinical and histopathological aspects and associated conditions of patients with Sweetís syndrome receiving care at a general hospital between January 2002 and March 2007.…”

Section: Introductionmentioning

confidence: 99%

Síndrome de Sweet: estudo de 73 casos, com ênfase nos achados histopatológicos

Rochael

Pantaleão

Vilar

et al. 2011

An. Bras. Dermatol.

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BACKGROUND: Sweet's syndrome refers to a set of cutaneous, systemic and histopathological alterations that occur in response to different stimuli, in a similar way to that occurring in erythema nodosum, erythema multiforme and leukocytoclastic vasculitis. The syndrome has been described in association with conditions such as infections, pregnancy, the use of certain medications and malignancy. OBJECTIVES: To evaluate the clinical and histopathological alterations occurring in this syndrome and to assess the association between these alterations and other conditions. METHODS: A retrospective study of 73 cases was conducted, evaluating data on the microscopic examination of skin lesions, as well as clinical and laboratory data. RESULTS: The majority of the patients were female (83.0%), white (49.2%) and between 30 and 60 years of age (73.8%). The principal alterations found were: erythymatous plaques (76.9%), papules (43.0%), pseudo-vesiculation (PV) (38.4%) and target lesions (18.5%). With respect to the associated conditions, upper respiratory tract infections (15.4%) and the use of medication (10.8%) were the most common. Other associations, albeit represented by only one case each, were: Hodgkin's lymphoma, pregnancy, ulcerative colitis, polycythemia vera and lupus erythematosus in a patient with acquired immune deficiency syndrome (AIDS). The principal microscopic findings were: neutrophils with leukocytoclasia (98.6%), collagen degeneration (87.7%), edema (74.0%) and PV (38.4%). The presence of eosinophils (41.1%) ranged from rare to abundant and was usually unrelated to the use of medication. Inflammatory infiltrate reached the deep epidermal layer in 47.9% of cases and panniculitis was found in 80.0% of cases in which the hypodermis was affected (10 cases). CONCLUSIONS: In general, these findings are in agreement with results published in the literature, emphasizing the frequent finding of eosinophils unrelated to drug use, panniculitis and the rare association with Hodgkin's lymphoma. This is the fifth report of an association between Sweet's syndrome and Hodgkin's disease. Keywords: Erythema Multiforme; Hodgkin's Disease; Panniculitis; Sweet's Syndrome.Resumo: FUNDAMENTOS: A síndrome de Sweet corresponde a um conjunto de alterações cutâneas, sistêmicas e histopatológicas como resposta a diversos estímulos, semelhantes ao eritema nodoso, ao eritema multiforme e à vasculite leucocitoclásica. São descritas condições associadas como infecção, gravidez, uso de drogas e malignidades. OBJETIVOS: Avaliar as alterações clínicas e histopatológicas da síndrome, relacionando-a a outras condições. MÉTODO: Estudo retrospectivo de 73 casos com avaliação microscópica de lesões cutâneas, dados clínicos e laboratoriais. RESULTADOS: Houve predomínio de mulheres (83,0%), brancas (49,2%), entre a quarta e a sexta décadas de vida (73,8%). Placas eritematosas (76,9%), pápulas (43,0%), pseudovesiculação (PV) (38,4%) e lesões em alvo (18,5%) foram as principais alterações. Entre as condições associadas, infecções de vi...

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“…8 By establishing that the dominant infiltrate in biopsies from some patients with Sweet's syndrome is composed of histiocytoid immature myeloid cells, not neutrophils, the authors conveyed 2 valuable lessons to colleagues in their field. First, they established that a diagnosis of Sweet's syndrome should not be dismissed in the face of a predominantly mononuclear dermal infiltrate.…”

Section: Introductionmentioning

confidence: 99%

Histiocytoid Neutrophilic Dermatoses and Panniculitides: Variations on a Theme

Chow¹,

Pasternak²,

Green³

et al. 2007

The American Journal of Dermatopathology

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Requena et al, in their article titled "Histiocytoid Sweet syndrome," in 2005, established that the dermal infiltrate in some patients with Sweet's syndrome is composed of histiocyte-like immature myeloid cells, not polymorphonuclear leukocytes as is the norm. With this premise in mind, we report on 6 cases of inflammatory skin disease in which the common denominator was a dermal and/or subcutaneous infiltrate of histiocytoid myeloid cells in patients with new-onset cutaneous eruptions and systemic symptoms. The cases were diverse clinically and microscopically, fell short of the criteria necessary for a diagnosis of classical Sweet's syndrome, and were difficult to categorize at the outset. The systemic manifestations ranged from malaise alone to a combination of fever, chills, night sweats, and polyarthralgia. The clinical morphology of the cutaneous eruptions varied from being papulovesicular in 1 patient to mainly consisting of erythematous plaques and nodules in the remainder. The dermatologists' differential diagnoses included Sweet's syndrome in 3 cases, a drug eruption in 2, and other entities such as erythema nodosum and Well's syndrome. Biopsies in all cases revealed a dermal and/or subcutaneous infiltrate composed predominantly of mononuclear histiocytoid cells of myeloid origin. With the benefit of detailed clinicopathologic correlation, the cases were classified for the purpose of this report as follows: Sweet's-like neutrophilic dermatosis, histiocytoid (3 cases); subcutaneous Sweet's syndrome, histiocytoid (2 cases); histiocytoid neutrophilic dermatosis, unspecified (1 case). In addition, we describe a further instructive case that exhibited overlap with those in the series but proved ultimately to represent leukemia cutis. The spectrum of observations in this report supports and expands the original concept of histiocytoid Sweet's syndrome.

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Histiocytoid Sweet Syndrome

Cited by 206 publications

References 20 publications

Bortezomib-induced histiocytoid Sweet syndrome

Bortezomib-induced histiocytoid Sweet syndrome

Síndrome de Sweet: estudo de 73 casos, com ênfase nos achados histopatológicos

Histiocytoid Neutrophilic Dermatoses and Panniculitides: Variations on a Theme

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