Histaminuria in Urticaria Pigmentosa

Diffuse cutaneous mastocytosis with multiple cutaneous mastocytomas

“…In the ultra-thin sections many mast cells showed evidence of degranulation, mostly of the vacuolization-expulsion type (Moriyasu & Yamura, 1973). The possibility of the synthesis of an abnormal secretory product is supported by the absence of oedema and dilated blood vessels in the presence of extensive degranulation, and by the absence of elevated urinary histamine excretion, in contrast to Demis' finding of elevated histamine levels in 24 h urine collections of patients with mastocytosis (Demis, Walton & Higdon, 1961). Furthermore, the ultrastructure of the granules, i.e.…”

Presentation of Telangiectasia Macularis Eruptiva Perstans as a Long-Standing Solitary Plaque Associated with Renal Carcinoma

“…Only 10% of the patients with cutaneous mastocytosis had resolution of their symptoms compared with 90% of the patients with childhood onset. 15 A familial TMEP has been described. Although most patients with TMEP present in adulthood, all the members of this family developed initial lesions during childhood.…”

Generalized Mastocytosis

“…However, the severity of symptoms cannot be correlated to the absolute value of the histamine level. It is true, meanwhile, that an in creased blood histamine level is often accompanied by aggravation of symptoms [12,35]. It is not always possible to demonstrate mastocytes in a biopsy specimen, because without special staining it is difficult to identi fy these cells [5,6,8].…”

“…Other antagonistic agents have been used with varying success, e.g. histidine decarboxylase inhibitor [4,32], a serotonin and histamine antagonist [28], reserpine [12,20] and L-hyoscyamine [5]. Protamine sulphate seems useful only if there is a distinctly demonstrable heparin effect in the circulation, expressed in a markedly increased clot ting time [22], Apart from antagonists, therapeutic attempts have been made with agents which degranulate mast cells.…”