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Cited by 20 publications
(15 citation statements)
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References 34 publications
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“…Interestingly, a concurrent blockade of the H 1 , 5-HT, and muscarinic receptors by the non-selective antagonist cyproheptadine provoked a significant increase of intake in a lipid drinking paradigm (Hartfield et al 2003a). This is consistent with the multifaceted pharmacological profile of AAPs as well as with the similar effects obtained from administering olanzapine (Hartfield et al 2003b), also confirming the involvement of hypothalamic histamine receptors in food and water intake (Ookuma et al 1993;Mercer et al 1994;Magrani et al 2004). Olanzapine has been shown to block histamine H 1 receptors (Richelson and Souder 2000) far more potently than other classes of antipsychotics.…”
Section: Aaps and Metabolic Dysregulation: Insulin Resistance On Metasupporting
confidence: 73%
“…Interestingly, a concurrent blockade of the H 1 , 5-HT, and muscarinic receptors by the non-selective antagonist cyproheptadine provoked a significant increase of intake in a lipid drinking paradigm (Hartfield et al 2003a). This is consistent with the multifaceted pharmacological profile of AAPs as well as with the similar effects obtained from administering olanzapine (Hartfield et al 2003b), also confirming the involvement of hypothalamic histamine receptors in food and water intake (Ookuma et al 1993;Mercer et al 1994;Magrani et al 2004). Olanzapine has been shown to block histamine H 1 receptors (Richelson and Souder 2000) far more potently than other classes of antipsychotics.…”
Section: Aaps and Metabolic Dysregulation: Insulin Resistance On Metasupporting
confidence: 73%
“…The efferent fibers of histaminergic neurons project widely throughout the brain (Schwartz et al 1991;Takada et al 1987). High densities of histaminergic fibers are found in the hypothalamus, with all nuclei including VMH receiving a strong or moderate innervation (Martinez-Mir et al 1990;Terao et al 2004). In CNS, histamine is synthesized from histidine by a specific enzyme, histidine decarboxylase (HDC), and signals through three receptor subtypes: histamine receptor 1, 2, and 3 (H 1 , H 2 , and H 3 ).…”
Section: Introductionmentioning
confidence: 99%
“…Even though histamine actions have been studied in the VMH (Alvarez and Donoso 1981;Jang et al 2001;Kow et al 2005) and the literature indicates its potential in modulating VMH functions, such as sexual behavior (Donoso and Broitman 1979) and feeding behavior (Aou et al 1995;Magrani et al 2004;Sakata and Yoshimatsu 1995), electrophysiological characterization of histamine action in the VMH is very limited. In our current study, we used whole cell patch-clamp recording to investigate the effect of histamine on VMH neurons.…”
Section: Introductionmentioning
confidence: 99%
“…Many biological agents given into the VMH have been demonstrated to affect feeding. Food intake is inhibited by administration of histamine (4,47), glucagon-like peptide 1 (70), serotonin agonists (25), urocortin (58), CCK (79), leptin (51), and insulin (78), whereas thyroid hormone (3,5,3Ј-triiodothyronine) (40), GABA or GABA agonists (32,34,35), norepinephrine (73), orexin (74), and NPY induce feeding after administration into the VMH (5,9,24,31,43,56,76).…”
mentioning
confidence: 99%