Histamine synthesis by mouse T lymphocytes through induced histidine decarboxylase.

Aoi, Rie; Oh, Chan‐Ho; Nakano, Kiwao

doi:10.1271/bbb1961.52.891

Cited by 12 publications

(16 citation statements)

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“…While we could not detect any increase in histamine or its major metabolite tele-methylhistamine in the conditioned media of PBMCs in the presence of IL-18, the induction of histidine decarboxylase was reported in monocyte/macrophage (26) and T lymphocytes (27) by LPS, IL-1, and TNF-␣ (50). Such inducible histamine appeared to be released after the synthesis without entering into the stable storage pool (26,27,50).…”

Section: Discussionmentioning

confidence: 55%

“…Such inducible histamine appeared to be released after the synthesis without entering into the stable storage pool (26,27,50). Therefore, it is speculated that inducible histamine may regulate the host immune response by modulating cytokine production in PBMCs.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the stable pool of histamine in mast cells and basophilic leukocytes, the presence of histamine with a different dynamic property, called inducible or nascent histamine, was suggested in the earlier works (24,25). Later, many groups reported the induction of histidine decarboxylase, a histamine-synthesizing enzyme, by LPS, cytokines, and lymphocyte mitogen in macrophages (26), T lymphocytes (27), and in many peripheral tissues (28,29). The synthesized histamine appeared not to enter the storage pool inside the cells, but rather was spontaneously released from the cells (30).…”

mentioning

confidence: 99%

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Histamine Is a Potent Inducer of IL-18 and IFN-γ in Human Peripheral Blood Mononuclear Cells

Kohka

Nishibori²,

Ishibashi³

et al. 2000

The Journal of Immunology

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Histamine (10−7 to 10−4 M) concentration-dependently stimulated the production of IL-18 and IFN-γ and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine in the same concentration range did not induce the production of IL-12 at all. The stimulatory or inhibitory effects of histamine on cytokine production were all antagonized by H2 receptor antagonists ranitidine and famotidine in a concentration-dependent manner, but not by H1 and H3 receptor antagonists. Selective H2 receptor agonists, 4-methylhistamine and dimaprit, mimicked the effects of histamine on five kinds of cytokine production. The EC50 values of histamine, 4-methylhistamine, and dimaprit for the production of IL-18 were 1.5, 1.0, and 3.8 μM, respectively. These findings indicated that histamine caused cytokine responses through the stimulation of H2 receptors. All effects of histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1β-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. The addition of recombinant human IL-18 to the culture concentration-dependently stimulated IL-12 and IFN-γ production and inhibited the IL-2 and IL-10 production. IFN-γ production induced by IL-18 was inhibited by anti-IL-12 Ab, showing the marked contrast of the effect of histamine. Thus histamine is a very important modulator of Th1 cytokine production in PBMCs and is quite unique in triggering IL-18-initiating cytokine cascade without inducing IL-12 production.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Histamine Is a Potent Inducer of IL-18 and IFN-γ in Human Peripheral Blood Mononuclear Cells

Kohka

Nishibori²,

Ishibashi³

et al. 2000

The Journal of Immunology

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“…Recent studies have identified other histamine-producing cells-monocytes/macrophages (Takamatsu et al 1996), T-lymphocytes (Aoi et al 1989), and vascular endothelial cells (Endo et al 1995)-in which histidine decarboxylase activity was induced by lipopolysaccharide, interleukin-1 ␤ , TNF-␣ , or concanavalin A. Histamine functions as a mediator of inflammation, an immunomodulator, a secretagogue of gastric acid secretion and a neurotransmitter in the CNS. It exerts these effects through the stimulation of three distinct subtypes of receptors, H 1 , H 2 , and H 3 , present on the target cells.…”

mentioning

confidence: 99%

Immunohistochemical Localization of Histamine N-Methyltransferase in Guinea Pig Tissues

Tahara

Nishibori

Ohtsuka

et al. 2000

J Histochem Cytochem.

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Histamine plays important roles in gastric acid secretion, inflammation, and allergic response. Histamine N-methyltransferase (HMT; EC 2.1.1.8) is crucial to the inactivation of histamine in tissues. In this study we investigated the immunohistochemical localization of this enzyme in guinea pig tissues using a rabbit polyclonal antibody against bovine HMT. The specificity of the antibody for guinea pig HMT was confirmed by Western blotting and the lack of any staining using antiserum preabsorbed with purified HMT. There was strong HMT-like immunoreactivity (HMT-LI) in the epithelial cells in the gastrointestinal tract, especially in the gastric body, duodenum, and jejunum. The columnar epithelium in the gallbladder was also strongly positive. Almost all the myenteric plexus from the stomach to the colon was stained whereas the submucous plexus was not. Other strongly immunoreactive cells included the ciliated cells in the trachea and the transitional epithelium of the bladder. Intermediately immunoreactive cells included islets of Langerhans, epidermal cells of the skin, alveolar cells in the lung, urinary tubules in the kidney, and epithelium of semiferous tubules. HMT-LI was present in specific structures in the guinea pig tissues. The widespread distribution of HMT-LI suggests that histamine has several roles in different tissues.

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“…Since these cells were found to exhibit relatively high enzyme activity and release histamine spontaneously, they fulfill the requirement for 'inducible' histamine. Although histamine synthesis was also reported in Con A-activated T lymphocytes previously (11), further supporting evidence should be required to establish the concept of T cell-derived histamine.…”

Section: Inducible Histamine Synthesis In Immune Cells Other Than Masmentioning

confidence: 81%

Recent Advances in Molecular Pharmacology of the Histamine Systems: Immune Regulatory Roles of Histamine Produced by Leukocytes

Tanaka

Ichikawa

2006

J Pharmacol Sci

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Abstract. Accumulating evidence has highlighted the importance of histamine in immune responses. The H 1 receptor is involved not only in allergic inflammatory reactions but also in augmentation of helper T cell (Th)1 responses, whereas H 2 receptor suppresses Th responses and participates in immune tolerance through interleukin-10 and transforming growth factor-β. Identification of the H 4 receptor, which binds to histamine with high affinity and of which expression is limited to the hematopoietic system, has enhanced the importance of histamine in immune responses. However, since a majority of previous studies has evaluated the effects of exogenous histamine, it remains largely unknown how endogenously produced histamine is involved in regulation of such kinds of immune responses. Insight into precise roles of histamine in the immune system can not be obtained without correct understanding of both the predominance of a certain type of histamine receptor and the regulation of histamine synthesis. Here we review a part of the recent progress in histamine research in the field of immunology with attention to the source of involved histamine.

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Histamine synthesis by mouse T lymphocytes through induced histidine decarboxylase.

Abstract: Histamine (Hm) mediates and modulates inflammations through a variety of immunoregulatory actions1 '2) and is generally accepted to be released from mast cells and basophil< upon activation of the cells with allergenreagin complex.3) In contrast we have pre

Cited by 12 publications

References 0 publications

Histamine Is a Potent Inducer of IL-18 and IFN-γ in Human Peripheral Blood Mononuclear Cells

Histamine Is a Potent Inducer of IL-18 and IFN-γ in Human Peripheral Blood Mononuclear Cells

Immunohistochemical Localization of Histamine N-Methyltransferase in Guinea Pig Tissues

Recent Advances in Molecular Pharmacology of the Histamine Systems: Immune Regulatory Roles of Histamine Produced by Leukocytes

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