Histamine in the brain of insects: a review

Nässel, Dick R.

doi:10.1002/(sici)1097-0029(19990115/01)44:2/3<121::aid-jemt6>3.0.co;2-f

Cited by 125 publications

(52 citation statements)

References 55 publications

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“…In contrast, histamine is exclusively produced in the TMN in zebrafish (Da'as et al, 2011), and thus is unlikely to be involved in regulating immune system function, although this remains a possibility. In Drosophila , histamine is primarily produced in photoreceptors, and perturbation of histamine signaling affects the detection of light cues that regulate sleep (Melzig et al, 1996; Nässel, 1999). Thus, while a Drosophila hdc hypomorph exhibits increased daytime sleep (Oh et al, 2013), this may result from impaired vision.…”

Section: Discussionmentioning

confidence: 99%

Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep

Chen

Singh

Oikonomou

et al. 2017

eNeuro

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Pharmacological studies in mammals and zebrafish suggest that histamine plays an important role in promoting arousal. However, genetic studies using rodents with disrupted histamine synthesis or signaling have revealed only subtle or no sleep/wake phenotypes. Studies of histamine function in mammalian arousal are complicated by its production in cells of the immune system and its roles in humoral and cellular immunity, which can have profound effects on sleep/wake states. To avoid this potential confound, we used genetics to explore the role of histamine in regulating sleep in zebrafish, a diurnal vertebrate in which histamine production is restricted to neurons in the brain. Similar to rodent genetic studies, we found that zebrafish that lack histamine due to mutation of histidine decarboxylase (hdc) exhibit largely normal sleep/wake behaviors. Zebrafish containing predicted null mutations in several histamine receptors also lack robust sleep/wake phenotypes, although we are unable to verify that these mutants are completely nonfunctional. Consistent with some rodent studies, we found that arousal induced by overexpression of the neuropeptide hypocretin (Hcrt) or by stimulation of hcrt-expressing neurons is not blocked in hdc or hrh1 mutants. We also found that the number of hcrt-expressing or histaminergic neurons is unaffected in animals that lack histamine or Hcrt signaling, respectively. Thus, while acute pharmacological manipulation of histamine signaling has been shown to have profound effects on zebrafish and mammalian sleep, our results suggest that chronic loss of histamine signaling due to genetic mutations has only subtle effects on sleep in zebrafish, similar to rodents.

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Section: Discussionmentioning

confidence: 99%

Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep

Chen

Singh

Oikonomou

et al. 2017

eNeuro

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“…There is much evidence to suggest that histamine acts as a neurotransmitter released from the photoreceptor synapse of insects and other arthropods. Histamine acts by directly gating chloride channels and inhibits the activity of central nervous circuits in arthropods [17, 18]. Diapause is mostly induced in H. armigera by short daylength signals which are received by photoreceptors in the brain.…”

Section: Discussionmentioning

confidence: 99%

Proteomic and metabolomic profiles of larval hemolymph associated with diapause in the cotton bollworm, Helicoverpa armigera

Zhang

2013

BMC Genomics

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BackgroundDiapause is programmed developmental arrest coupled with the depression of metabolic activity and the enhancement of stress resistance. Pupal diapause is induced by environmental signals and is prepared during the prediapause phase. In the cotton bollworm, Helicoverpa armigera, the prediapause phase, which contains two sub-phases, diapause induction and preparation, occurs in the larval stage. Here, we performed parallel proteomic and metabolomic analyses on H. armigera larval hemolymph during the prediapause phase.ResultsBy two-dimensional electrophoresis, 37 proteins were shown to be differentially expressed in diapause-destined larvae. Of these proteins, 28 were successfully identified by MALDI-TOF/TOF mass spectrometry. Moreover, a total of 22 altered metabolites were found in diapause-destined larval hemolymph by GC-MS analysis, and the levels of 17 metabolites were elevated and 5 were decreased.ConclusionsThe proteins and metabolites with significantly altered levels play different roles in diapause-destined larvae, including diapause induction, metabolic storage, immune response, stress tolerance, and others. Because hemolymph circulates through the whole body of an insect, these differences found in diapause-destined larvae most likely correspond to upstream endocrine signals and would further influence other organ/tissue activities to determine the insect’s fact: diapause or development.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2164-14-751) contains supplementary material, which is available to authorized users.

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“…Most LNs in insects are GABAergic, but other neurotransmitters (e.g., dopamine, histamine) and neuropep-tides (e.g., tachykinin-related peptides, FMRFamiderelated peptides, A-type allatostain, Manduca sexta allatotropin, orcokinin) are also expressed in AL LNs (Homberg and Mü ller, 1999;Nä ssel, 1999;Hofer et al, 2005;Schachtner et al, 2005;Nä ssel and Homberg, 2006;Berg et al, 2007), although their function is so far unclear. Some of the neuropeptides are co-localized with GABA, suggesting that they act as co-transmitters with GABA.…”

Section: Non-gabaergic Lnsmentioning

confidence: 99%

Comprehensive morphological identification and GABA immunocytochemistry of antennal lobe local interneurons in Bombyx mori

Seki

Kanzaki

2007

J of Comparative Neurology

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The insect antennal lobe (AL) is the structural and functional analog of the olfactory bulb of mammals, in which odor information is spatially and/or temporally represented by functional glomerular units. Local interneurons (LNs) play critical roles through intra- and interglomerular communication to shape the output from the AL to higher brain centers; however, the function and even the components of LNs are unclear. We have used morphological and immunocytochemical approaches to examine LNs in the silkworm moth, Bombyx mori. First, we comprehensively analyzed the morphological variation of LNs. One hundred fifty-three AL LNs were intracellularly stained, analyzed in three dimensions with a confocal microscope, and subdivided into five morphological types based on differences in the arborization region in the AL and dendritic profiles within the glomeruli. Two global multiglomerular types arborized in the macroglomerular complex (MGC) and in most ordinary glomeruli, and the other three oligoglomerular types innervated some ordinary glomeruli with or without the MGC. Second, we performed double-labeling of Lucifer Yellow staining of a single LN combined with gamma-aminobutyric acid (GABA) immunocytochemistry. The two global multiglomerular types and two of the oligoglomerular types were GABA-immunoreactive, but the third oligoglomerular type, which innervates the MGC and some ordinary glomeruli, included some GABA-immunonegative neurons, suggesting the existence of a non-GABAergic subtype. These results suggest that the complex neural circuits of the AL are composed of several morphologically different types of LNs, most of which are inhibitory.

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Histamine in the brain of insects: a review

Cited by 125 publications

References 55 publications

Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep

Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep

Proteomic and metabolomic profiles of larval hemolymph associated with diapause in the cotton bollworm, Helicoverpa armigera

Comprehensive morphological identification and GABA immunocytochemistry of antennal lobe local interneurons in Bombyx mori

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