“…For example, inadequate regulation of the autonomic nervous system (ANS) (Ebinger et al, 2006, Geraud and Donnet, 2013, Melek et al, 2007), derangement of serotonin metabolism (Dussor, 2014, Hoffmann and Goadsby, 2014, Vollbracht and Rapoport, 2014), insensitive reaction to reduced oxygen in the vasculature and tissue (Friberg et al, 1994, Lacombe et al, 1992, Raddant and Russo, 2014), disruption of the normal pain pathways (Kroger and May, 2015), peculiar platelet metabolism (Danese et al, 2014, Gawel and Rose, 1982, Hanington, 1989), neurogenic inflammation (Tajti et al, 2015) and etc. (Alstadhaug, 2014). Researchers have yet to disseminate a unified theory to account for the different aspects of the complex pathophysiology of migraine.…”