2014
DOI: 10.1111/head.12293
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Abstract: Background.-Histamine has been studied in both health and disease since the initial description a century ago. With its vasodilative effect, it was suggested early on to be involved in the pathophysiology of migraine. Over the past 25 years, much has been learned about histamine as a neurotransmitter in the central nervous system. The role of this neurotransmitter system in migraine has not been previously reviewed.Objective.-Discuss a potential role of the brain histaminergic system in migraine.Methods.-Unstr… Show more

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Cited by 61 publications
(45 citation statements)
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References 120 publications
(221 reference statements)
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“…In contrast with these findings, a Spanish group claimed, in nonscientific newspapers, that 90% of patients with migraine show DAO deficiency, which could be improved with the ingestion of a DAO capsule before the meals, leading to migraine improvement (http://www.lavanguardia.com/salud/20130306/54369041093/cientificos-demuestran-que-una-enzima-sirve-para-prevenir-el-90-de-migranas.html) Histamine acts through four metabotropic histamine receptors, which are all G‐protein‐coupled (GPCR) (HRH1, HRH2, HRH3, and HRH4) transducer extracellular signals via Gq, Gs, and Gi/o proteins, respectively. In general, histamine modulates inflammatory and allergic responses via HRH1, gastric acid secretion through HRH2, neurotransmitter release in the central nervous system (CNS) via HRH3, and chemotaxis and inflammatory mediators release via HRH4 . The brain stores and releases histamine from mast cells and histaminergic neurons of the tuberomammillary nucleus of the posterior basal hypothalamus.…”
Section: Clinical Epidemiological Biochemical Experimental and Phmentioning
confidence: 99%
“…In contrast with these findings, a Spanish group claimed, in nonscientific newspapers, that 90% of patients with migraine show DAO deficiency, which could be improved with the ingestion of a DAO capsule before the meals, leading to migraine improvement (http://www.lavanguardia.com/salud/20130306/54369041093/cientificos-demuestran-que-una-enzima-sirve-para-prevenir-el-90-de-migranas.html) Histamine acts through four metabotropic histamine receptors, which are all G‐protein‐coupled (GPCR) (HRH1, HRH2, HRH3, and HRH4) transducer extracellular signals via Gq, Gs, and Gi/o proteins, respectively. In general, histamine modulates inflammatory and allergic responses via HRH1, gastric acid secretion through HRH2, neurotransmitter release in the central nervous system (CNS) via HRH3, and chemotaxis and inflammatory mediators release via HRH4 . The brain stores and releases histamine from mast cells and histaminergic neurons of the tuberomammillary nucleus of the posterior basal hypothalamus.…”
Section: Clinical Epidemiological Biochemical Experimental and Phmentioning
confidence: 99%
“…The underlying mechanisms of allergy-related effects on learning and memory are still unclear. Although the underlying mechanisms are still elusive, it has been proposed that peripheral histamine may impact central histaminergic neurotransmission and hypothalamic activity via the circumventricular organs that lack a blood-brain barrier or via activation of negative feedback mechanisms of central histamine release [39]. For example, cytokines have been found to act on brain functions by passing the blood-brain barrier or via vagal nerve stimulation [27,28].…”
Section: Discussionmentioning
confidence: 99%
“…However, both H3R and H4R ligands may theoretically have migraine prophylactic properties. Despite being promising drug targets for several diseases, the lack of specificity and undesired side effects will probably be a major problem (81).…”
Section: Pharmacotherapy In Migraine and Sleepmentioning
confidence: 99%