Histamine in Migraine and Brain

Abstract

Background.-Histamine has been studied in both health and disease since the initial description a century ago. With its vasodilative effect, it was suggested early on to be involved in the pathophysiology of migraine. Over the past 25 years, much has been learned about histamine as a neurotransmitter in the central nervous system. The role of this neurotransmitter system in migraine has not been previously reviewed.Objective.-Discuss a potential role of the brain histaminergic system in migraine.Methods.-Unst…