Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

Thomas, Carissa M.; Hong, Teresa; Pijkeren, Jan Peter van; Hemarajata, Peera; Trinh, Dan V.; Hu, Weidong; Britton, Robert A.; Kalkum, Markus; Versalovic, James

doi:10.1371/journal.pone.0031951

Cited by 386 publications

(354 citation statements)

References 75 publications

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“…Probiotic Lactobacillus-mediated interventions have been shown to downregulate TNF-a in the colon, enhance gut barrier activity, and reduce overall reductions in colitis-related pathology. [46][47][48][49] Additionally, treatment with probiotic Lactobacillus reuteri in mice abrogates the stressor-induced increases in the severity of the inflammatory response to a colonic pathogen. 40 Interestingly, though previous studies have found that Lactobacillus is reduced in the stool, 18,20,21,50 this study showed a reduction in mucosal epithelium-associated Lactobacillus but not in luminal lactobacilli, implying that psychological stressor exposure can have a distinct effects upon groups of mucosal microbiota compared to their luminal counterparts.…”

Section: Discussionmentioning

confidence: 99%

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

Galley

Yu²,

Kumar

et al. 2014

Gut Microbes

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The commensal microbiota of the human gastrointestinal tract live in a largely stable community structure, assisting in host physiological and immunological functions. Changes to this structure can be injurious to the health of the host, a concept termed dysbiosis. Psychological stress is a factor that has been implicated in causing dysbiosis, and studies performed by our lab have shown that restraint stress can indeed shift the cecal microbiota structure as well as increase the severity of a colonic infection caused by Citrobacter rodentium. However, this study, like many others, have focused on fecal contents when examining the effect of dysbiosis-causing stimuli (e.g. psychological stress) upon the microbiota. Since the mucosa-associated microbiota have unique properties and functions that can act upon the host, it is important to understand how stressor exposure might affect this niche of bacteria. To begin to understand whether chronic restraint stress changes the mucosa-associated and/or luminal microbiota mice underwent 7 16-hour cycles of restraint stress, and the microbiota of both colonic tissue and fecal contents were analyzed by sequencing using nextgen bacterial tag-encoded FLX amplicon technology (bTEFAP) pyrosequencing. Both control and stress groups had significantly different mucosa-associated and luminal microbiota communities, highlighting the importance of focusing gastrointestinal community structure analysis by microbial niche. Furthermore, restraint stress was able to disrupt both the mucosa-associated and luminally-associated colonic microbiota by shifting the relative abundances of multiple groups of bacteria. Among these changes, there was a significant reduction in the immunomodulatory commensal genus Lactobacillus associated with colonic mucosa. The relative abundance of Lactobacillus spp. was not affected in the lumen. These results indicate that stressor-exposure can have distinct effects upon the colonic microbiota situated at the mucosal epithelium in comparison to the luminal-associated microbiota.

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Section: Discussionmentioning

confidence: 99%

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

Galley

Yu²,

Kumar

et al. 2014

Gut Microbes

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“…81 Lactobacillus reuteri, a commensal in the human gut, expresses histidine decarboxylase that converts histidine to histamine. Therefore, a change in the population of this gut microbe can potentially modulate the levels of circulating histidine and histamine, 82 which in turn can affect the concentration of CNS histamine. 83 In another example, rats that are given Bifidobacterium infantis for 14 days showed increased concentrations of the serotonin precursor tryptophan in plasma, an effect that may be mediated by the altered expression of indoleamine-2,3-dioxygenase, a key enzyme in the kynurenine pathway of tryptophan degradation.…”

Section: Effect Of Bacterial Metabolites On the Central Nervous Systemmentioning

confidence: 99%

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

Yarandi

Peterson

Treisman

et al. 2016

J Neurogastroenterol Motil

222

134

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Gut microbiome is an integral part of the Gut-Brain axis. It is becoming increasingly recognized that the presence of a healthy and diverse gut microbiota is important to normal cognitive and emotional processing. It was known that altered emotional state and chronic stress can change the composition of gut microbiome, but it is becoming more evident that interaction between gut microbiome and central nervous system is bidirectional. Alteration in the composition of the gut microbiome can potentially lead to increased intestinal permeability and impair the function of the intestinal barrier. Subsequently, neuro-active compounds and metabolites can gain access to the areas within the central nervous system that regulate cognition and emotional responses. Deregulated inflammatory response, promoted by harmful microbiota, can activate the vagal system and impact neuropsychological functions. Some bacteria can produce peptides or short chain fatty acids that can affect gene expression and inflammation within the central nervous system. In this review, we summarize the evidence supporting the role of gut microbiota in modulating neuropsychological functions of the central nervous system and exploring the potential underlying mechanisms.

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“…The model probiotic organism L. reuteri ATCC PTA 6475 (L. reuteri 6475) also produces histamine (18). L. reuteri-derived histamine suppressed TNF production by TLR2-activated THP-1 cells via activation of the histamine receptor type 2 (H 2 ) and inhibition of MEK/extracellular signal-regulated kinase mitogen-activated protein (MAP) kinase signaling.…”

mentioning

confidence: 99%

Lactobacillus reuteri-Specific Immunoregulatory Gene rsiR Modulates Histamine Production and Immunomodulation by Lactobacillus reuteri

et al. 2013

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Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

Cited by 386 publications

References 75 publications

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

Lactobacillus reuteri-Specific Immunoregulatory Gene rsiR Modulates Histamine Production and Immunomodulation by Lactobacillus reuteri

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