Histamine and collagen levels in the lathyritic chick embryos after administration of 48/80

Dąbrowski, R.; Szczepanowska, A

doi:10.1007/bf01983159

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The immediate response of rat dural, periosteal and mesenteric mast cells to compound 48/80 indicated a primary rather than a secondary effect from other more delayed actions of compound 48/80 (Christoffersen & Poulsen, 1979;Gietzen, 1983;Gietzen et aI., 1983;Henrich & Zimmerman, 1984;Rice & Whitsett, 1984;Dabrowski & Szczepanowska, 1985). Also the similar effects of compound 48/80 on mast cells in the mesentery, periosteum and dura attest to the specificity of that action on CTMC.…”

Section: Evidence For Dispersion Of Dural Mast Cell Constituentsmentioning

confidence: 81%

Linear arrays of homogenous mast cells in the dura mater of the rat

et al. 1991

View full text Add to dashboard Cite

Using fluorescence histochemistry, 5-HT, histamine and heparin were colocalized in a large population of cells in the dura mater thereby identifying them as mast cells. In addition, because these cells were highly sensitive to compound 48/80 and were densely packed with granules of a consistent density, they were identified specifically as 'connective tissue' mast cells. Other types of mast cells, i.e. 'mucosal' or 'neurolipomastocytes', were not present in the rat dura mater. 5-HT immunohistochemistry was the best technique for demonstrating that there were populations of mast cells, one associated with each of the two layers of dura. Although shaped differently the type of mast cell in each layer was the same. It was observed that mast cell shape is dependent on the contiguity, density and orientation of its surrounding elements, not its type. In general, mast cells in the outer layer were aligned parallel to the middle meningeal artery and those in the inner layer were parallel to trigeminal nerve branches that coursed obliquely across the middle meningeal artery. Examination of cross-sections of dura revealed that most mast cells also were aligned at the interface between the two dural layers. The linear orientation of mast cells in two planes of each layer suggests a programmed lamellar seeding of these cells during development of the dura. This study also demonstrated that the majority of dural mast cells were more closely related to other connective tissue elements than to blood vessels and nerves. These results (1) are compatible with the suggestion that dural mast cells play a non-obligatory role in the neuroinflammatory response, (2) leave open to question the role of the dural mast cell in headache or the regulation of blood flow, and (3) support evidence that dural mast cells play an important role in connective tissue related functions, e.g. development, inflammatory response to injury and wound repair.

show abstract

Section: Evidence For Dispersion Of Dural Mast Cell Constituentsmentioning

confidence: 81%

Linear arrays of homogenous mast cells in the dura mater of the rat

et al. 1991

View full text Add to dashboard Cite

show abstract

“…For example, it inhibits calmodulin-dependent platelet aggregation (45) and reacts with substance P receptors, producing a noncytotoxic noncalmodulin-related inhibition of the re-lease of phosphatidyl choline from respiratory Type I1 epithelial cells (46). In addition, compound 48/80 may affect cells indirectly by way of its metabolites, especially the aldehydes that can interfere with collagen maturation (47) and that have been reported to be toxic to the liver (48). Although compound 48/80 does not produce pathologic changes in hepatocyte morphology such as edema (30), decreases in the uptake of fluorescent latex particles by Kupffer cells and corroborative changes in Kupffer cell morphology have been reported which are suggestive of inactivation (49).…”

mentioning

confidence: 99%

Elevated Blood Glucose after Compound 48/80 Treatment Is Not Related to Hepatic Mast Cell Degranulation in Rats

Dimlich

Reilly

1986

Experimental Biology and Medicine

View full text Add to dashboard Cite

Blood glucose, hepatic glycogen, and the histological integrity of hepatic mast cells, were evaluated in anesthetized rats receiving iv injections of 0.125 mg/kg body weight compound 48/80 (a mast cell degranulator) and/or of 0.001 to 10.0 mg/kg body weight lodoxamide tromethamine (an inhibitor of mast cell degranulation). A nonglucogenic dose of lodoxamide, 0.00 1 mg/kg body weight, prevented dissipation of histochemically demonstrable fluorescence in mast cells (degranulation) without inhibiting compound 48/80-induced hyperglycemia and hepatic glycogenolysis. These results suggest that this glucotropic response is independent of compound 48/80-evoked release of mediators such as serotonin from mast cells. o

show abstract

Histamine and collagen levels in the lathyritic chick embryos after administration of 48/80

Cited by 2 publications

References 5 publications

Linear arrays of homogenous mast cells in the dura mater of the rat

Linear arrays of homogenous mast cells in the dura mater of the rat

Elevated Blood Glucose after Compound 48/80 Treatment Is Not Related to Hepatic Mast Cell Degranulation in Rats

Contact Info

Product

Resources

About