Histamine‐2 Receptor Blockers Alter the Fecal Microbiota in Premature Infants

Gupta, Raegan W.; Tran, Lynn; Norori, Johana; Ferris, Michael J.; Eren, A. Murat; Taylor, Christopher M.; Dowd, Scot E.; Penn, Duna

doi:10.1097/mpg.0b013e318282a8c2

Cited by 96 publications

(55 citation statements)

References 33 publications

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“…(13) Surveys of the fecal microbiota in premature infants demonstrate that dysbiosis due to increased Enterobacteriaceae is associated with NEC. (7, 25) Early dysbiosis may predispose premature infants to subsequent development of NEC,(26) and increased administration of antibiotics(27, 28) and acid-blocking agents(29, 30) are both associated with dysbiosis and with increased susceptibility to NEC. In experiment A, we found marked dysbiosis in the FF group with high levels of Enterobacteriaceae that was partially attenuated by B. infantis , however this pattern was not seen in experiment B.…”

Section: Discussionmentioning

confidence: 99%

Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota

et al. 2014

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Background Probiotics decrease the risk of necrotizing enterocolits (NEC). We sought to determine the impact of Bifidobacterium longum subsp. infantis (B. infantis) in the established rat model of NEC. Methods Rat pups delivered one day prior to term gestation were assigned to one of three groups: dam-fed (DF), formula-fed (FF), or fed with formula supplemented with 5 × 106 CFU B. infantis per day (FF+Binf). Experimental pups were exposed to hypoxia and cold stress. Ileal tissue was examined for pathology and expression of inflammatory mediators, antimicrobial peptides, and goblet-cell products. Ceca were assessed for bacterial composition by analysis of 16S rRNA sequence. Results Administration of B. infantis significantly reduced the incidence of NEC, decreased expression of Il6, Cxcl1, Tnfa, Il23, and iNOS, and decreased expression of the antimicrobial peptides Reg3b and Reg3g. There was significant microbial heterogeneity both within groups and between experiments. The cecal microbiota was not significantly different between the FF and FF+Binf groups. Bifidobacteria were not detected in the cecum in significant numbers. Conclusions In the rat model, the inflammation associated with NEC was attenuated by administration of probiotic B. infantis. Dysbiosis was highly variable precluding determination of the precise role of the microbiota in experimental NEC.

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Section: Discussionmentioning

confidence: 99%

Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota

et al. 2014

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“…Functional genomics has been used to predict hospitalizations in psychiatric patients and may be feasible in select clinical populations, such as those recovering from a CDI (56). Going forward, it will also be important to understand the extent to which less severe stresses to the microbiome (e.g., minor infections not requiring hospitalization and common medications known to influence the microbiome [antibiotics, proton pump inhibitors (57), H 2 receptor antagonists (58), and antidepressants (59)]) influence patients' risk for developing severe sepsis, and whether these risks depend on the dosage and duration of medication. While we await these sorts of confirmatory studies, it may be possible to incorporate microbiome measurements into studies of selective oropharyngeal and/or gut decontamination and to monitor microbiome recovery and infections rates beyond hospital discharge.…”

Section: Discussionmentioning

confidence: 99%

Hospitalization Type and Subsequent Severe Sepsis

Prescott

Dickson²,

Rogers

et al. 2015

Am J Respir Crit Care Med

133

102

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Rationale: Hospitalization is associated with microbiome perturbation (dysbiosis), and this perturbation is more severe in patients treated with antimicrobials.Objectives: To evaluate whether hospitalizations known to be associated with periods of microbiome perturbation are associated with increased risk of severe sepsis after hospital discharge.Methods: We studied participants in the U.S. Health and Retirement Study with linked Medicare claims (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010). We measured whether three hospitalization types associated with increasing severity of probable dysbiosis (non-infection-related hospitalization, infection-related hospitalization, and hospitalization with Clostridium difficile infection [CDI]) were associated with increasing risk for severe sepsis in the 90 days after hospital discharge. We used two study designs: the first was a longitudinal design with between-person comparisons and the second was a self-controlled case series design using within-person comparison.Measurements and Main Results: We identified 43,095 hospitalizations among 10,996 Health and Retirement Study-Medicare participants. In the 90 days following non-infectionrelated hospitalization, infection-related hospitalization, and hospitalization with CDI, adjusted probabilities of subsequent admission for severe sepsis were 4.1% (95% confidence interval [CI], 3.8-4.4%), 7.1% (95% CI, 6.6-7.6%), and 10.7% (95% CI, 7.7-13.8%), respectively. The incidence rate ratio (IRR) of severe sepsis was 3.3-fold greater during the 90 days after hospitalizations than during other observation periods. The IRR was 30% greater after an infectionrelated hospitalization versus a non-infection-related hospitalization. The IRR was 70% greater after a hospitalization with CDI than an infection-related hospitalization without CDI.Conclusions: There is a strong dose-response relationship between events known to result in dysbiosis and subsequent severe sepsis hospitalization that is not present for rehospitalization for nonsepsis diagnoses.

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“…Dysbiosis in this population is extremely common and multifactorial. Evidence supporting a direct association between dysbiosis and NEC includes the following: First, antibiotic administration is associated with alterations in the intestinal microbiota and with increased risk of NEC (88, 90); second, acid suppression is associated with alterations in the intestinal microbiota and with increased risk of NEC (91, 92); and third, probiotic administration is associated with a decrease in dysbiosis and a decrease in NEC (93, 94). …”

Section: Milk Glycome–based Enrichment Of a Protective Infant Microbimentioning

confidence: 99%

The Impact of the Milk Glycobiome on the Neonate Gut Microbiota

Pacheco¹,

Barile

Underwood³

et al. 2015

Annu. Rev. Anim. Biosci.

152

142

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Human milk is a complete source of nourishment for the infant. Exclusive breastfeeding not only sustains the infant’s development but also guides the proliferation of a protective intestinal microbiota. Among the many components of milk that modulate the infant gut microbiota, the milk glycans, which comprise free oligosaccharides, glycoproteins, and glycolipids, are increasingly recognized as drivers of microbiota development and overall gut health. These glycans may display pleiotropic functions, conferring protection against infectious diseases and also acting as prebiotics, selecting for the growth of beneficial intestinal bacteria. The prebiotic effect of milk glycans has direct application to prevention of diseases such as necrotizing enterocolitis, a common and devastating disease of preterm infants. In this article, we review the impact of the human (and bovine) milk glycome on gut health through establishment of a milk-oriented microbiota in the neonate.

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Histamine‐2 Receptor Blockers Alter the Fecal Microbiota in Premature Infants

Cited by 96 publications

References 33 publications

Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota

Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota

Hospitalization Type and Subsequent Severe Sepsis

The Impact of the Milk Glycobiome on the Neonate Gut Microbiota

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