Hippuric acid and 3-car☐y-4-methyl-5-propyl-2-furanpropionic acid in serum and urine

Small Molecule Metabolite Biomarker Candidates in Urine from Mice Exposed to Formaldehyde

“…Additionally, hippuric acid is a component of non-protein nitrogen containing metabolites which result from protein and nucleic acid metabolism, and are found in urine [ 26 ]. Accordingly, down-regulation of hippuric acid levels has been reported in cases of renal disease [ 27 , 28 ]. In the present study, urinary levels of hippuric acid were significantly decreased in the FA inhalation group.…”

Small Molecule Metabolite Biomarker Candidates in Urine from Mice Exposed to Formaldehyde

“…Additionally, hippuric acid is a component of non-protein nitrogen containing metabolites which result from protein and nucleic acid metabolism, and are found in urine [ 26 ]. Accordingly, down-regulation of hippuric acid levels has been reported in cases of renal disease [ 27 , 28 ]. In the present study, urinary levels of hippuric acid were significantly decreased in the FA inhalation group.…”

The harmful intestinal microbial community accumulates during DKD exacerbation and microbiome–metabolome combined validation in a mouse model

“…Hippuric acid is involved in phenylalanine metabolism and considered as a microbiota-derived uremic solute and related to chronic kidney disease ( 45 ). The clinical study has demonstrated that the plasma level of hippuric acid is shown to be elevated in hemodialysis patients with chronic renal failure compared with healthy controls and hospital patients without kidney disease ( 46 ). Surprisingly, healthy microbiota transplantation can significantly decrease the serum hippuric acid level, which is comparable with the healthy control mice, suggesting that remodeling healthy intestinal microbial community may decrease some uremic toxins specifically and improve DKD phenotypes.…”

Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

“…Both hippuric acid and its precursor benzoic acid have been implicated in early-stage DN [43]. Plasma levels of hippuric acid were shown to be elevated in haemodialysed patients with chronic renal failure when compared to healthy controls and hospital patients without kidney disease [57]. Several differentiating metabolites are involved in vitamin metabolism.…”

Small Molecule Metabolite Biomarker Candidates in Urine from Mice Exposed to Formaldehyde

“…Additionally, hippuric acid is a component of non-protein nitrogen containing metabolites which result from protein and nucleic acid metabolism, and are found in urine [ 26 ]. Accordingly, down-regulation of hippuric acid levels has been reported in cases of renal disease [ 27 , 28 ]. In the present study, urinary levels of hippuric acid were significantly decreased in the FA inhalation group.…”

The harmful intestinal microbial community accumulates during DKD exacerbation and microbiome–metabolome combined validation in a mouse model

“…Hippuric acid is involved in phenylalanine metabolism and considered as a microbiota-derived uremic solute and related to chronic kidney disease ( 45 ). The clinical study has demonstrated that the plasma level of hippuric acid is shown to be elevated in hemodialysis patients with chronic renal failure compared with healthy controls and hospital patients without kidney disease ( 46 ). Surprisingly, healthy microbiota transplantation can significantly decrease the serum hippuric acid level, which is comparable with the healthy control mice, suggesting that remodeling healthy intestinal microbial community may decrease some uremic toxins specifically and improve DKD phenotypes.…”

Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

“…Both hippuric acid and its precursor benzoic acid have been implicated in early-stage DN [43]. Plasma levels of hippuric acid were shown to be elevated in haemodialysed patients with chronic renal failure when compared to healthy controls and hospital patients without kidney disease [57]. Several differentiating metabolites are involved in vitamin metabolism.…”

Small Molecule Metabolite Biomarker Candidates in Urine from Mice Exposed to Formaldehyde

“…Additionally, hippuric acid is a component of non-protein nitrogen containing metabolites which result from protein and nucleic acid metabolism, and are found in urine [ 26 ]. Accordingly, down-regulation of hippuric acid levels has been reported in cases of renal disease [ 27 , 28 ]. In the present study, urinary levels of hippuric acid were significantly decreased in the FA inhalation group.…”

The harmful intestinal microbial community accumulates during DKD exacerbation and microbiome–metabolome combined validation in a mouse model

“…Hippuric acid is involved in phenylalanine metabolism and considered as a microbiota-derived uremic solute and related to chronic kidney disease ( 45 ). The clinical study has demonstrated that the plasma level of hippuric acid is shown to be elevated in hemodialysis patients with chronic renal failure compared with healthy controls and hospital patients without kidney disease ( 46 ). Surprisingly, healthy microbiota transplantation can significantly decrease the serum hippuric acid level, which is comparable with the healthy control mice, suggesting that remodeling healthy intestinal microbial community may decrease some uremic toxins specifically and improve DKD phenotypes.…”

Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

“…Both hippuric acid and its precursor benzoic acid have been implicated in early-stage DN [43]. Plasma levels of hippuric acid were shown to be elevated in haemodialysed patients with chronic renal failure when compared to healthy controls and hospital patients without kidney disease [57]. Several differentiating metabolites are involved in vitamin metabolism.…”