Hippocampal volume reduction is associated with intellectual functions in adolescents with congenital heart disease

Latal, Beatrice; Patel, Parshva; Liamlahi, Rabia; Knirsch, Walter; O’Gorman, Ruth L.; Rhein, Michael von

doi:10.1038/pr.2016.122

Cited by 48 publications

(72 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regional analysis revealed smaller volumes in the groups with CHD for cerebral white matter, cortical grey matter, cerebellum, thalamus, basal ganglia, hippocampus, and corpus callosum . However, only the difference in corpus callosum volume remained significant after controlling for total brain volume . Finally, Watson et al .…”

Section: Resultsmentioning

confidence: 91%

“…This review also summarizes the associations between brain structures and functional outcomes uncovered to date in young people with CHD. Overall, structural abnormalities measured both by conventional and by quantitative MRI were associated with poorer outcomes . More specifically, the presence of structural brain abnormalities identified by conventional MRI were associated with poorer performance on tests of intelligence, executive function, attention/hyperactivity, social cognition, motor performance, visuospatial/visuomotor skills, and academic achievement .…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Structural brain abnormalities in adolescents and young adults with congenital heart defect: a systematic review

Bolduc

Lambert

Ganeshamoorthy

et al. 2018

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 93%

Structural brain abnormalities in adolescents and young adults with congenital heart defect: a systematic review

Bolduc

Lambert

Ganeshamoorthy

et al. 2018

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…There was some overlap in the distributions of cortical difference between the d-TGA and SV groups confined to the parietal lobe. While previous study of a heterogeneous group of CHD patients has revealed reduction in total GM volume, cortical surface area, cerebellum, basal ganglia, hippocampus, and thalamus, parcellation of specific cortical gyri and evaluation of cortical thickness was not performed (25,26). Studies of children, adolescents, and young adults with CHD and 22q11.2 deletion syndrome revealed volume reductions in parietal, temporal, and occipital regions, as well as hippocampus (27,28).…”

Section: Articles Watson Et Almentioning

confidence: 96%

Reduced cortical volume and thickness and their relationship to medical and operative features in post-Fontan children and adolescents

et al. 2017

View full text Add to dashboard Cite

Background:We compared brain cortical and subcortical gray matter volumes and cortical thickness between postFontan patients and healthy controls, and examined brain anatomical associations with operative and medical history characteristics. Methods: Post-Fontan (n = 128 volumes; n = 115 thickness) and control subjects (n = 48 volumes; n = 45 thickness) underwent brain MRI at ages 10-19 y. Subcortical and cortical volumes and cortical thicknesses were measured for intergroup comparison. Associations between brain measures and clinical measures were assessed in the Fontan group. results: Widespread, significant reduction in brain volumes and thicknesses existed in the Fontan group compared to controls, spanning all brain lobes and subcortical gray matter. Fontan subjects treated with vs. without the Norwood procedure had smaller volumes in several terminal clusters, but did not differ in cortical thickness. Older age at first operation and increasing numbers of cardiac catheterizations, operative complications, and catheterization complications were associated with lower regional volumes and thicknesses. Increasing numbers of operative complications and cardiac catheterizations were associated with smaller regional volumes in the Norwood group. conclusion: The post-Fontan adolescent brain differs from the normal control brain. Some of these differences are associated with potentially modifiable clinical variables, suggesting that interventions might improve long-term neurocognitive outcome.c ongenital heart disease (CHD) is the most common congenital anomaly, with single ventricle (SV) defects occurring in nearly 10% of patients with CHD (1). Patients with SV, particularly hypoplastic left heart syndrome (HLHS), have higher mortality and morbidity than those with other types of CHD, but their survival has steadily increased for several decades (2). The Fontan procedure, as well as staged palliation

show abstract

“…The incidence of WM injury reported is highly variable depending on the age at the time of surgery and the type of CHD. A recent study demonstrated reduced hippocampal volumes in adolescents who had undergone CPB surgery 58 ; the hippocampus is an important structure for learning and memory. Although several studies have addressed the effects of heart surgery on brain injury, the developmental abnormalities before surgery have received more attention recently.…”

Section: Neuroimaging In Chdmentioning

confidence: 98%

Neurodevelopmental Abnormalities and Congenital Heart Disease

Morton

Ishibashi

Jonas

2017

Circulation Research

154

View full text Add to dashboard Cite

In the past two decades it has become evident that individuals born with congenital heart disease (CHD) are at risk of developing life-long neurological deficits. Multifactorial risk factors contributing to neurodevelopmental abnormalities associated with CHD have been identified; however the underlying etiologies remain largely unknown and efforts to address this issue have only recently begun. There has been a dramatic shift in focus from newly acquired brain injuries associated with corrective and palliative heart surgery to antenatal and preoperative factors governing altered brain maturation in CHD. In this review, we describe key time windows of development during which the immature brain is vulnerable to injury. Special emphasis is placed on the dynamic nature of cellular events and how CHD may adversely impact the cellular units and networks necessary for proper cognitive and motor function. In addition, we describe current gaps in knowledge and offer perspectives about what can be done to improve our understanding of neurological deficits in CHD. Ultimately, a multidisciplinary approach will be essential in order to prevent or improve adverse neurodevelopmental outcomes in individuals surviving CHD.

show abstract

Hippocampal volume reduction is associated with intellectual functions in adolescents with congenital heart disease

Abstract: In adolescent survivors of cardiopulmonary bypass surgery for CHD, specific brain regions such as the hippocampus may show long-term persistent alteration and correlate with intellectual deficits, particularly with verbal and memory functions.

Cited by 48 publications

References 44 publications

Structural brain abnormalities in adolescents and young adults with congenital heart defect: a systematic review

Structural brain abnormalities in adolescents and young adults with congenital heart defect: a systematic review

Reduced cortical volume and thickness and their relationship to medical and operative features in post-Fontan children and adolescents

Neurodevelopmental Abnormalities and Congenital Heart Disease

Contact Info

Product

Resources

About