Abstract.The apolipoprotein E (APOE) 4 allele is the major genetic risk factor for the development of late-onset Alzheimer's disease (AD), whereas the presence of the APOE 2 allele seems to confer protection. Here, we report that healthy young APOE 4 carriers have statistically significantly smaller hippocampal volumes than APOE 2 carriers, while no differences were detected between the two groups in memory performance. The difference in hippocampal morphology is cognitively/clinically silent in young adultho…
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