Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: A meta-analysis

Woon, Fu Lye; Sood, Shabnam; Hedges, Dawson W.

doi:10.1016/j.pnpbp.2010.06.016

Cited by 343 publications

(249 citation statements)

References 65 publications

Supporting

Mentioning

222

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, this inflammation-induced amygdala response may also contribute to the association between increased CRP levels and heightened psychophysiological hyperarousal in traumatized individuals with PTSD (Michopoulos et al, 2015b). The hippocampus is another brain structure within the medial temporal lobe whose function, structure, and functional connectivity with other regions is comprised in individuals with PTSD, GAD, and PD (Cui et al, 2016;Fani et al, 2012b;Woon et al, 2010). Hippocampal alterations, including smaller hippocampal volume, are associated with both emotional and cognitive deficits in individuals with PTSD (Bremner, 2006).…”

Section: Consequences Of Increased Inflammation In Fearand Anxiety-bamentioning

confidence: 99%

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

Michopoulos

Powers

Gillespie

et al. 2016

Neuropsychopharmacol

520

376

View full text Add to dashboard Cite

The study of inflammation in fear-and anxiety-based disorders has gained interest as growing literature indicates that proinflammatory markers can directly modulate affective behavior. Indeed, heightened concentrations of inflammatory signals, including cytokines and C-reactive protein, have been described in posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), panic disorder (PD), and phobias (agoraphobia, social phobia, etc.). However, not all reports indicate a positive association between inflammation and fear-and anxiety-based symptoms, suggesting that other factors are important in future assessments of inflammation's role in the maintenance of these disorders (ie, sex, co-morbid conditions, types of trauma exposure, and behavioral sources of inflammation). The most parsimonious explanation of increased inflammation in PTSD, GAD, PD, and phobias is via the activation of the stress response and central and peripheral immune cells to release cytokines. Dysregulation of the stress axis in the face of increased sympathetic tone and decreased parasympathetic activity characteristic of anxiety disorders could further augment inflammation and contribute to increased symptoms by having direct effects on brain regions critical for the regulation of fear and anxiety (such as the prefrontal cortex, insula, amygdala, and hippocampus). Taken together, the available data suggest that targeting inflammation may serve as a potential therapeutic target for treating these fear-and anxiety-based disorders in the future. However, the field must continue to characterize the specific role pro-inflammatory signaling in the maintenance of these unique psychiatric conditions.

show abstract

Section: Consequences Of Increased Inflammation In Fearand Anxiety-bamentioning

confidence: 99%

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

Michopoulos

Powers

Gillespie

et al. 2016

Neuropsychopharmacol

520

376

View full text Add to dashboard Cite

show abstract

“…The amygdala is particularly vulnerable to stressors early in life. Reduced hippocampal volumes (Woon, et al 2010) and increased amygdala volumes (Tottenham, et al 2010) have been associated with early life stress.…”

Section: Amygdala and Early Stressmentioning

confidence: 99%

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

Bonaz¹,

Pellissier²,

Sinniger³

et al. 2012

The Amygdala - A Discrete Multitasking Manager

View full text Add to dashboard Cite

show abstract

“…Reduced frontal lobe volume was associated with worse subjective sleep quality in combat-exposed Gulf War Veterans, regardless of PTSD diagnosis [25]. Many previous studies have demonstrated reduced hippocampal volume in PTSD, especially in severe cases [26]. However, recent findings suggest that difficulties with sleep may substantially account for the relationship between PTSD and hippocampal volume [27].…”

Section: Rdoc Framework-based Correlates Of Trauma and Sleepmentioning

confidence: 95%

Understanding Recent Insights in Sleep and Posttraumatic Stress Disorder from a Research Domain Criteria (RDoC) Framework

Kelly

Killgore

Haynes

2016

Curr Sleep Medicine Rep

View full text Add to dashboard Cite

Posttraumatic stress disorder (PTSD) is associated with sleep disturbances, including insomnia, nightmares, sleep-disordered breathing, and REM abnormalities. Recent studies have expanded our knowledge of the neurobiology of trauma and sleep. In addition, intervention research has provided valuable information about how sleep treatments affect PTSD symptoms and how PTSD treatments affect sleep symptoms. This review of recent literature aims to move away from the categorical approach that currently dominates our conceptualization of trauma response and sleep disorders. Possible mechanisms of both trauma and sleep disturbance are posed within the framework put forth by the National Institute of Mental Health's (NIMH) Research Domain Criteria (RDoC) project. By examining domains of dysfunction that cut across disorders, RDoC may guide future research and treatment of the maladaptive neurobiological and behavioral correlates of both trauma and sleep disturbances.

show abstract

Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: A meta-analysis

Cited by 343 publications

References 65 publications

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

Understanding Recent Insights in Sleep and Posttraumatic Stress Disorder from a Research Domain Criteria (RDoC) Framework

Contact Info

Product

Resources

About