2018
DOI: 10.1017/s0022149x18000755
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Abstract: An experimental Taenia crassiceps mouse model was used to assess the role of Taenia solium metacestode factor (Fac) in human neurocysticercosis. Intraperitoneal infection with T. crassiceps metacestodes or subcutaneous inoculation with a T. crassiceps metacestode factor (Fac) produced significant impairment of performance (learning) in the Barnes maze and induced bilateral hippocampal sclerosis in mice. Several staining techniques revealed important cell dispersion, extensive apoptosis and cell loss in the den… Show more

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Cited by 7 publications
(4 citation statements)
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“…In this model, Taenia crassiceps infection leads to great damage and apoptosis in the hippocampus, mainly in the dentate gyrus, hillus, CA1, CA2, CA3 and neighboring brain regions of the animal. Some of these findings parallel those observed in HS in MTLE-HS patients ( 81 , 82 ). It is also interesting to note that, in these animal models, there is also gender-specific differential expression of cytokines in specific regions of the brain, including the hippocampus ( 83 ), a finding that may help to explain the gender differences observed in patients with cNCC and MTLE-HS.…”
Section: Discussionsupporting
confidence: 80%
“…In this model, Taenia crassiceps infection leads to great damage and apoptosis in the hippocampus, mainly in the dentate gyrus, hillus, CA1, CA2, CA3 and neighboring brain regions of the animal. Some of these findings parallel those observed in HS in MTLE-HS patients ( 81 , 82 ). It is also interesting to note that, in these animal models, there is also gender-specific differential expression of cytokines in specific regions of the brain, including the hippocampus ( 83 ), a finding that may help to explain the gender differences observed in patients with cNCC and MTLE-HS.…”
Section: Discussionsupporting
confidence: 80%
“…In the second essay, mice implanted ip with T. crassiceps metacestodes or inoculated with T. crassiceps MF showed a significant impairment of performance (learning) in the Barnes maze, as well as extensive apoptosis in all regions of both hippocampi, and an intense deterioration of the adjacent cortex and apoptosis of endothelial cells were confirmed. 24,25 Finally, data from the last study using transmission electron microscopy confirmed the HS reported in the previous essays and unveiled other abnormalities in the myelin structure of the CA3 neuron axons, as well as in their internal axonal mitochondria. Apoptosis of endothelial cells, surrounded by large tears in the adjacent nervous tissue and apoptotic astrocytes, was also observed (nonpublished data).…”
Section: Introductionsupporting
confidence: 80%
“…These damages and behaviors were observed in mice either implanted ip with T. crassiceps metacestodes or with T. crassiceps MF. 24,25 This HS induced experimentally in an animal model by a substance secreted by T. crassiceps metacestodes may be analogous to that observed in patients with NCC produced by T. solium MF.…”
Section: Introductionmentioning
confidence: 65%
“…Apoptosis of hippocampal cells may be related to a breakdown of the blood-brain barrier determined by the presence of circulating T. crassiceps metacestode factor. 18 Clinically, it has been well-documented that dead cysts may cause arachnoiditis, ependymitis, and hydrocephalus, 19 which is one of the reasons for using corticosteroids to control inflammation during the antiparasitic treatment. 20 A few studies have cautioned about the risk associated with intraoperative rupture of T. solium cysts, which may lead to ventriculitis 21,22 ; however, recent studies downplayed these risks.…”
Section: Discussionmentioning
confidence: 99%